{"id":"W4309411724","doi":"10.1002/1878-0261.13343","title":"<scp>SMG1</scp> , a nonsense‐mediated <scp>mRNA</scp> decay ( <scp>NMD</scp> ) regulator, as a candidate therapeutic target in multiple myeloma","year":2022,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Cell biology; Biology; Molecular biology; Apoptosis; Unfolded protein response; Kinase; Chemistry; Endoplasmic reticulum; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002320899,0.000317672,0.0002175094,0.000279838,0.0001404552,0.0002764977,0.000156946,0.000252462,0.0004474685],"category_scores_gemma":[0.00007883961,0.00006191643,0.0001939276,0.0002626166,0.0001932456,0.0001309848,0.0001118971,0.0004558231,0.0001414697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004256454,"about_ca_system_score_gemma":0.0002188236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005921425,"about_ca_topic_score_gemma":0.001043624,"domain_scores_codex":[0.9999235,0.00001454701,0.000005396289,0.00001842421,0.00002238483,0.00001572472],"domain_scores_gemma":[0.9999434,0.00001466104,0.00001615596,0.00000549137,0.000007754145,0.00001252354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001932292,0.00005052717,0.0006441094,0.0001342881,0.000008109026,0.0001032976,0.00001628795,0.0003499159,0.9862449,0.0003363543,0.0001065973,0.01181241],"study_design_scores_gemma":[0.00002718379,0.001601554,0.006521562,0.00001350402,0.00004783783,0.0005633802,0.00001863108,0.001082679,0.9817485,0.0001244865,0.008243968,0.000006735643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9506928,0.04133667,0.004383146,0.0004237647,0.00005219908,0.00007367304,0.000397254,0.0001202053,0.002520315],"genre_scores_gemma":[0.986995,0.008470796,0.002825418,0.00008756624,0.00001765572,0.00002485495,0.0005081292,0.000009344692,0.001061308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005921425,"threshold_uncertainty_score":0.003088355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01146920878127661,"score_gpt":0.269298770822505,"score_spread":0.2578295620412284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}