{"id":"W4309417209","doi":"10.1093/noajnl/vdac174","title":"Upfront BRAF/MEK inhibitors for treatment of high-grade glioma: A case report and review of the literature","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; CancerCare Manitoba; McGill University; Centre Hospitalier de l’Université de Montréal; Université Laval; Université de Montréal; Montreal Children's Hospital; Izaak Walton Killam Health Centre; Centre hospitalier universitaire de Québec; University of Manitoba; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Dabrafenib; Trametinib; Medicine; Pleomorphic xanthoastrocytoma; Oncology; Context (archaeology); Internal medicine; MEK inhibitor; Glioma; Clinical trial; Targeted therapy; Vemurafenib; Cancer research; Cancer; MAPK/ERK pathway; Astrocytoma; Metastatic melanoma; Biology; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004580998,0.0009727079,0.001322906,0.005744372,0.0007628436,0.001171845,0.001149417,0.001641182,0.001611196],"category_scores_gemma":[0.001718092,0.0004183541,0.0009624449,0.005844226,0.0007824263,0.001588695,0.0006113942,0.0009309705,0.000751538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006771065,"about_ca_system_score_gemma":0.001184839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001406745,"about_ca_topic_score_gemma":0.002756205,"domain_scores_codex":[0.9993056,0.00007817068,0.0003063864,0.0001001408,0.0001446272,0.00006508188],"domain_scores_gemma":[0.9986988,0.0004646186,0.0005348996,0.0000430101,0.000160389,0.00009827165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0001063398,0.0001412243,0.01541775,0.029978,0.0005437872,0.7501041,0.001015217,0.0004032806,0.003859472,0.0009516733,0.01397602,0.183503],"study_design_scores_gemma":[0.0000227745,0.00008979392,0.007228544,0.005955709,0.0009747252,0.9467945,0.0008335609,0.000201878,0.0008032431,0.0004621499,0.03658449,0.00004860631],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.02521123,0.9687203,0.001079511,0.001331682,0.0004767348,0.00007635937,0.0002035306,0.0000523042,0.00284834],"genre_scores_gemma":[0.1689078,0.8228065,0.002101816,0.002726302,0.002006208,0.00006390866,0.0004542922,0.00002577132,0.0009073138],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005744372,"threshold_uncertainty_score":0.005389988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01477446651615667,"score_gpt":0.3108484129247586,"score_spread":0.296073946408602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}