{"id":"W4309419386","doi":"10.1111/acel.13739","title":"Cysteine restriction‐specific effects of sulfur amino acid restriction on lipid metabolism","year":2022,"lang":"en","type":"article","venue":"Aging Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Institute of Environmental Health Sciences; Norges Forskningsråd; Ministerstvo Zdravotnictví Ceské Republiky","keywords":"Methionine; Cysteine; Serine; Biology; Amino acid; Biochemistry; Lipid metabolism; Glutathione; Metabolism; Polyunsaturated fatty acid; Triglyceride; Cysteine metabolism; Internal medicine; Endocrinology; Fatty acid; Cholesterol; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000200972,0.0001236124,0.000133742,0.0001155025,0.0001579267,0.00001186619,0.0001374605,0.000060296,0.00001583255],"category_scores_gemma":[0.0000342354,0.0001330346,0.00008396592,0.0002255535,0.0000206737,0.00000282725,0.0001073264,0.0001293547,0.00001094417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002064285,"about_ca_system_score_gemma":0.0000280753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002405279,"about_ca_topic_score_gemma":7.429765e-7,"domain_scores_codex":[0.9989371,0.000161398,0.0002094702,0.0003025628,0.0002213322,0.000168092],"domain_scores_gemma":[0.9993652,0.00003486751,0.0001494565,0.00035369,0.00005028673,0.00004648298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003867973,0.00009741339,0.0004628009,0.0000243785,0.00001292002,0.000002959009,0.00003518195,0.0009618781,0.9961436,0.00009346397,0.001035267,0.001091462],"study_design_scores_gemma":[0.0004924756,0.0004817881,0.005797229,0.000005696922,0.00002080521,9.113958e-7,0.00002100787,0.00003040502,0.9111055,0.00008898212,0.08183294,0.0001222612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913639,0.004591483,0.0007275479,0.00006890048,0.0007403675,0.0001795419,0.000013792,0.00001762378,0.002296829],"genre_scores_gemma":[0.9966384,0.001450969,0.0002590722,0.00004762553,0.0003673856,0.00002668308,0.0001630534,0.00002414112,0.001022727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0850381,"threshold_uncertainty_score":0.5424995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006439241734630519,"score_gpt":0.2135639766580845,"score_spread":0.207124734923454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}