{"id":"W4309419386","doi":"10.1111/acel.13739","title":"Cysteine restriction‐specific effects of sulfur amino acid restriction on lipid metabolism","year":2022,"lang":"en","type":"article","venue":"Aging Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Institute of Environmental Health Sciences; Norges Forskningsråd; Ministerstvo Zdravotnictví Ceské Republiky","keywords":"Methionine; Cysteine; Serine; Biology; Amino acid; Biochemistry; Lipid metabolism; Glutathione; Metabolism; Polyunsaturated fatty acid; Triglyceride; Cysteine metabolism; Internal medicine; Endocrinology; Fatty acid; Cholesterol; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001916684,0.0004320467,0.0004537851,0.0003561596,0.0001351109,0.0003359882,0.0002160118,0.0003745315,0.001438768],"category_scores_gemma":[0.0002334477,0.000154746,0.0004040915,0.0001950652,0.0003708238,0.0002227056,0.0003244062,0.0006407361,0.0001913517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002310989,"about_ca_system_score_gemma":0.0002688561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009402166,"about_ca_topic_score_gemma":0.001827856,"domain_scores_codex":[0.9997979,0.00003623943,0.00002461802,0.00007232574,0.00003009734,0.00003874095],"domain_scores_gemma":[0.9996438,0.00004253784,0.0001065233,0.00005939322,0.0000420522,0.0001056502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002209518,0.0001095008,0.0006866425,0.00007475913,0.00003857187,0.00003992686,0.00001646678,0.00002677583,0.9948071,0.00004262825,0.00004014441,0.001908069],"study_design_scores_gemma":[0.0001116393,0.003650591,0.05180616,0.00002396639,0.000180657,0.0003213598,0.00007128248,0.0004367727,0.9406957,0.0001226007,0.002556567,0.00002260155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963781,0.001463664,0.001001866,0.00008322826,0.00003243947,0.00002692385,0.0003968745,0.00005897385,0.000557905],"genre_scores_gemma":[0.9932754,0.001181783,0.001811204,0.0001470161,0.00002253733,0.00006921863,0.0009595155,0.00004398482,0.00248946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001438768,"threshold_uncertainty_score":0.004813135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006439241734630519,"score_gpt":0.2135639766580845,"score_spread":0.207124734923454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}