{"id":"W4309438117","doi":"10.1016/j.jaut.2022.102946","title":"NFκB pathway dysregulation due to reduced RelB expression leads to severe autoimmune disorders and declining immunity","year":2022,"lang":"en","type":"article","venue":"Journal of Autoimmunity","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Immunodeficiency Canada","keywords":"RELB; Common variable immunodeficiency; Immune dysregulation; Immunology; Autoimmunity; Immune system; Exome sequencing; Primary immunodeficiency; Downregulation and upregulation; Cancer research; Immunodeficiency; Transcription factor; Biology; CIITA; Loss function; Medicine; Genetics; T cell; NFKB1; Mutation; Phenotype; MHC class II; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002704549,0.0007870184,0.0005396627,0.0005431144,0.0002396078,0.0005148074,0.0003340174,0.0006283709,0.003587785],"category_scores_gemma":[0.0003546008,0.0002850466,0.0005178291,0.0002666815,0.0005210465,0.0002894891,0.0003781972,0.001561889,0.0009517069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001958276,"about_ca_system_score_gemma":0.0002575517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002089032,"about_ca_topic_score_gemma":0.0002289481,"domain_scores_codex":[0.9995721,0.00008974617,0.00005342145,0.0001214025,0.00007934867,0.00008402465],"domain_scores_gemma":[0.9994581,0.00005009913,0.0002027723,0.00007712458,0.00003422138,0.0001776312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002901476,0.00007364809,0.0003723618,0.00004781772,0.00001751482,0.0008915206,0.00001190773,0.00005817848,0.9969207,0.0001458972,0.00009726184,0.001073093],"study_design_scores_gemma":[0.0002096933,0.001489599,0.04128471,0.00005920223,0.0001917898,0.03403312,0.0003205811,0.00215758,0.9115654,0.001289911,0.007350367,0.00004787805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897829,0.002241623,0.004726388,0.0003035858,0.0001403881,0.00002874702,0.0005518754,0.0003591799,0.001865272],"genre_scores_gemma":[0.9942228,0.0007914937,0.002033599,0.0001178546,0.00003640527,0.0000251156,0.0004260416,0.00007141312,0.002275185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003587785,"threshold_uncertainty_score":0.01200235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01257689831449679,"score_gpt":0.2539589316349559,"score_spread":0.2413820333204591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}