{"id":"W4309438117","doi":"10.1016/j.jaut.2022.102946","title":"NFκB pathway dysregulation due to reduced RelB expression leads to severe autoimmune disorders and declining immunity","year":2022,"lang":"en","type":"article","venue":"Journal of Autoimmunity","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Immunodeficiency Canada","keywords":"RELB; Common variable immunodeficiency; Immune dysregulation; Immunology; Autoimmunity; Immune system; Exome sequencing; Primary immunodeficiency; Downregulation and upregulation; Cancer research; Immunodeficiency; Transcription factor; Biology; CIITA; Loss function; Medicine; Genetics; T cell; NFKB1; Mutation; Phenotype; MHC class II; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00186776,0.0002310214,0.0003691488,0.000222228,0.0007316059,0.00005941357,0.000553599,0.0001269546,0.00006993359],"category_scores_gemma":[0.0005789225,0.0002344725,0.0001552122,0.0003100001,0.00005735727,0.00002262942,0.000909673,0.0006995006,0.000003599943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001031045,"about_ca_system_score_gemma":0.0002740141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006496756,"about_ca_topic_score_gemma":0.00001312595,"domain_scores_codex":[0.9976913,0.0006659404,0.0006791749,0.0002493889,0.0004068663,0.0003072742],"domain_scores_gemma":[0.9984685,0.00007645774,0.0004745459,0.0005992222,0.0002048068,0.0001765157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005867779,0.0001388952,0.001280539,0.00001429999,0.00004134276,0.00001197006,0.001696859,0.007838501,0.9792169,0.00001633503,0.000577326,0.00858026],"study_design_scores_gemma":[0.003277224,0.005488026,0.2430498,0.0002941276,0.00008243816,0.001019166,0.003632442,0.0002708228,0.6706123,0.0006990148,0.07048768,0.001086921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965966,0.0006592395,0.00110211,0.000647622,0.000496266,0.0002380995,0.00002365995,0.00002058355,0.0002157802],"genre_scores_gemma":[0.9960844,0.00003524443,0.00306452,0.0003291547,0.0001038365,0.00001667279,0.00004546668,0.0000429369,0.0002777712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3086045,"threshold_uncertainty_score":0.9561511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01257689831449679,"score_gpt":0.2539589316349559,"score_spread":0.2413820333204591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}