{"id":"W4309447787","doi":"10.3389/frph.2022.998913","title":"Pre-clinical evaluation of antiproteases as potential candidates for HIV-1 pre-exposure prophylaxis","year":2022,"lang":"en","type":"article","venue":"Frontiers in Reproductive Health","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Imperial College London","keywords":"Serpin; Cystatin; Immunology; Biology; Ex vivo; Protease; Proteases; Protease inhibitor (pharmacology); Population; Indinavir; In vivo; Virology; Virus; Medicine; Cystatin C; Viral disease; Sida; Viral load; Endocrinology; Antiretroviral therapy; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004403631,0.000143521,0.0004575917,0.0002094073,0.0003349581,0.000005321201,0.0001979666,0.00008702734,0.0002726515],"category_scores_gemma":[0.001021017,0.0001316362,0.000118684,0.0002324683,0.0002495301,0.00006810806,0.0001136657,0.0003979382,0.00001885204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003916246,"about_ca_system_score_gemma":0.001389823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007766947,"about_ca_topic_score_gemma":0.00002682886,"domain_scores_codex":[0.9958291,0.002176674,0.0005853867,0.0007632967,0.0002036053,0.0004419451],"domain_scores_gemma":[0.9988022,0.00007000394,0.0003081872,0.0005206499,0.0002543344,0.00004457519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01144128,0.003602781,0.5711367,0.0002568787,0.0008933513,0.000007535498,0.003360585,0.0008354986,0.001973579,0.00006264888,0.1429223,0.2635068],"study_design_scores_gemma":[0.02451521,0.03552932,0.8478765,0.00009697022,0.0002609133,0.0001090895,0.005691813,0.0004879014,0.01776152,0.006115286,0.06089168,0.0006637324],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9676936,0.02156763,0.001040778,0.001465272,0.001882157,0.005250681,0.0009999694,0.00002749485,0.00007238918],"genre_scores_gemma":[0.9942532,0.0001859502,0.001438419,0.00003831486,0.0000850705,0.001345797,0.001079031,0.00001753751,0.001556692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2767398,"threshold_uncertainty_score":0.5367967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02933554009325798,"score_gpt":0.3631302331066719,"score_spread":0.3337946930134139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}