{"id":"W4309447787","doi":"10.3389/frph.2022.998913","title":"Pre-clinical evaluation of antiproteases as potential candidates for HIV-1 pre-exposure prophylaxis","year":2022,"lang":"en","type":"article","venue":"Frontiers in Reproductive Health","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Imperial College London","keywords":"Serpin; Cystatin; Immunology; Biology; Ex vivo; Protease; Proteases; Protease inhibitor (pharmacology); Population; Indinavir; In vivo; Virology; Virus; Medicine; Cystatin C; Viral disease; Sida; Viral load; Endocrinology; Antiretroviral therapy; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006201666,0.0003987021,0.0006612039,0.0003156367,0.0002006187,0.0005338294,0.0003754098,0.0004190059,0.002563924],"category_scores_gemma":[0.0005712629,0.0001262091,0.0002547855,0.0002138298,0.0001934414,0.0002161056,0.0001596429,0.0007801991,0.0002994664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002062435,"about_ca_system_score_gemma":0.0003456413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002578756,"about_ca_topic_score_gemma":0.0009307927,"domain_scores_codex":[0.9997954,0.00006954566,0.00001501416,0.00002230806,0.00005192581,0.00004575593],"domain_scores_gemma":[0.9997187,0.00008397538,0.00005873411,0.00001254157,0.00005838941,0.00006753347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01471934,0.005812325,0.01511842,0.002197792,0.0002094176,0.001129607,0.0002748997,0.0007126682,0.668905,0.0004699725,0.001053536,0.289397],"study_design_scores_gemma":[0.002501559,0.2422268,0.08151836,0.0004589815,0.0007215554,0.003947222,0.0006156324,0.001896802,0.6034716,0.0003362409,0.06225721,0.00004809202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9442953,0.04820677,0.002022794,0.0005321604,0.0001296739,0.0008683171,0.0003315885,0.00007071217,0.003542625],"genre_scores_gemma":[0.9765424,0.0162556,0.003800558,0.0002533228,0.00008395983,0.0002614793,0.0004535675,0.000009605009,0.002339642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002563924,"threshold_uncertainty_score":0.008577168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02933554009325798,"score_gpt":0.3631302331066719,"score_spread":0.3337946930134139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}