{"id":"W4309449430","doi":"10.3390/cancers14225687","title":"Discovery of Novel Lin28 Inhibitors to Suppress Cancer Cell Stemness","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; U.S. Department of Defense","keywords":"LIN28; SOX2; CD44; microRNA; Cancer research; Cancer stem cell; Cancer; In silico; Cancer cell; Homeobox protein NANOG; Stem cell; Computational biology; Chemistry; Biology; Bioinformatics; Cell; Cell biology; Transcription factor; Biochemistry; Induced pluripotent stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001350946,0.0005762741,0.0004770414,0.0003670589,0.0001373113,0.0002885842,0.0002923172,0.0002078678,0.001811007],"category_scores_gemma":[0.0001158578,0.0001826954,0.0003277586,0.0002033438,0.0001380976,0.0001520632,0.0002232211,0.0004386991,0.0004738125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004131893,"about_ca_system_score_gemma":0.0004284173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006365181,"about_ca_topic_score_gemma":0.002805763,"domain_scores_codex":[0.9999491,0.0000080729,0.000003229491,0.00001100033,0.0000170083,0.00001157152],"domain_scores_gemma":[0.9999669,0.000005847778,0.000007694138,0.000002461268,0.000006338151,0.00001078603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004959276,0.0005011886,0.001018607,0.0004357098,0.0001077189,0.0003299308,0.00004454045,0.008414024,0.9407443,0.001230887,0.001002509,0.04567457],"study_design_scores_gemma":[0.0008318842,0.003585323,0.003066599,0.00005484192,0.0002293497,0.0008391794,0.00004306493,0.01366824,0.9475476,0.0005047627,0.02959189,0.00003730063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9442793,0.01920814,0.02252369,0.0004802095,0.00008636944,0.0007170808,0.001769563,0.0007024052,0.0102332],"genre_scores_gemma":[0.9557716,0.01378792,0.02026719,0.0002857624,0.00001964105,0.0002169979,0.002196575,0.00007650672,0.007377818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001811007,"threshold_uncertainty_score":0.006058395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226940188884031,"score_gpt":0.2539885603269478,"score_spread":0.2417191584381075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}