{"id":"W4309449430","doi":"10.3390/cancers14225687","title":"Discovery of Novel Lin28 Inhibitors to Suppress Cancer Cell Stemness","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; U.S. Department of Defense","keywords":"LIN28; SOX2; CD44; microRNA; Cancer research; Cancer stem cell; Cancer; In silico; Cancer cell; Homeobox protein NANOG; Stem cell; Computational biology; Chemistry; Biology; Bioinformatics; Cell; Cell biology; Transcription factor; Biochemistry; Induced pluripotent stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008315164,0.0001026061,0.0001140528,0.00003064385,0.00008236232,0.00001175581,0.0002110067,0.00004108335,0.0001068228],"category_scores_gemma":[0.00001308496,0.0001071823,0.00007048032,0.0001289976,0.00003698048,0.000007614693,0.0002174783,0.00006760278,8.483815e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002717048,"about_ca_system_score_gemma":0.0004008683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009137771,"about_ca_topic_score_gemma":0.0001635516,"domain_scores_codex":[0.9991964,0.00002707253,0.0001746731,0.0002615474,0.0001769439,0.0001633931],"domain_scores_gemma":[0.9995521,0.000004416986,0.00008934596,0.0002479231,0.00004733087,0.00005891118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009699455,0.00003045533,0.0003509017,0.00002692923,0.00001748081,4.394306e-7,0.0001156518,0.008810713,0.9684561,0.00003196557,0.02154804,0.0005142848],"study_design_scores_gemma":[0.0004580184,0.0001608308,0.0001013097,0.00001023793,0.000007551178,7.993992e-7,0.0005108608,0.00006268788,0.8820145,0.000001410895,0.1165279,0.0001439075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948462,0.001298313,0.0005879313,0.0001333566,0.001083452,0.0002706227,0.0003751472,0.000008227878,0.001396763],"genre_scores_gemma":[0.9952666,0.00007753712,0.0001201014,0.0005015638,0.0002402264,0.0002383486,0.00007268343,0.0000201056,0.003462894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09497981,"threshold_uncertainty_score":0.4370766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226940188884031,"score_gpt":0.2539885603269478,"score_spread":0.2417191584381075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}