{"id":"W4309455459","doi":"10.3390/cancers14225597","title":"The NAMPT Inhibitor FK866 Increases Metformin Sensitivity in Pancreatic Cancer Cells","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"Metformin; NAD+ kinase; Pancreatic cancer; Cancer research; Cancer; Cancer cell; Biology; Pharmacology; Internal medicine; Cell culture; Endocrinology; Medicine; Diabetes mellitus; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000835843,0.0002338997,0.0004130997,0.0002175411,0.0001884162,0.0002899662,0.0001499447,0.0002741171,0.001366865],"category_scores_gemma":[0.0001072755,0.0001320528,0.0002352686,0.0002379268,0.000112344,0.0001440807,0.0002058295,0.0006079896,0.0004014154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002269247,"about_ca_system_score_gemma":0.0001884428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008770913,"about_ca_topic_score_gemma":0.001373351,"domain_scores_codex":[0.999895,0.00001602511,0.00001617463,0.00002176202,0.00002556541,0.00002545105],"domain_scores_gemma":[0.9999394,0.00001080008,0.00001514587,0.000008424248,0.000007296602,0.00001888264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000686508,0.0001479545,0.0004566613,0.0001089862,0.00001377773,0.00006106659,0.00002088184,0.0001960582,0.9927498,0.00005781707,0.0003064865,0.00519396],"study_design_scores_gemma":[0.00009755354,0.001269991,0.01257945,0.00001591941,0.00003287865,0.0003506565,0.00004704721,0.00171046,0.9791708,0.00005376569,0.004660014,0.00001144611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991769,0.002877515,0.001195459,0.0002278354,0.0001013436,0.00003755487,0.0008910754,0.0001837886,0.002716503],"genre_scores_gemma":[0.9933138,0.001671188,0.00169953,0.0001315159,0.00001403789,0.00004284282,0.001032886,0.00001873743,0.002075392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001366865,"threshold_uncertainty_score":0.00457257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007769734437861324,"score_gpt":0.2368609143852682,"score_spread":0.2290911799474068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}