{"id":"W4309467340","doi":"10.1126/sciadv.abo6764","title":"Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer’s disease progression and heterogeneity","year":2022,"lang":"en","type":"article","venue":"Science Advances","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Montreal Neurological Institute and Hospital","funders":"National Institute on Aging; Canadian Institutes of Health Research; Health Canada; University of California, San Diego; Genentech; National Institutes of Health; IXICO; Servier; Bristol-Myers Squibb; Canada First Research Excellence Fund; Eisai; Novo Nordisk; Northern California Institute for Research and Education; H. Lundbeck A/S; Rush University; McGill University; University of Southern California; Pfizer; BioClinica; Biogen; Fondation Brain Canada; Eli Lilly and Company; U.S. Department of Defense; National Center for Advancing Translational Sciences; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Ionis Pharmaceuticals; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Epigenomics; Metabolomics; Transcriptome; Dementia; Disease; Computational biology; Biology; Proteomics; Omics; DNA methylation; Bioinformatics; Neuroscience; Medicine; Pathology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001308183,0.0004782633,0.0006370158,0.002245349,0.0003238919,0.001254966,0.0002930966,0.0002734872,0.0006777689],"category_scores_gemma":[0.00173033,0.0001375445,0.0005856329,0.001816293,0.0003815168,0.0008444826,0.001051087,0.0006264178,0.0001683306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003899734,"about_ca_system_score_gemma":0.000731326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002459333,"about_ca_topic_score_gemma":0.00463185,"domain_scores_codex":[0.9995607,0.00009856209,0.00004371715,0.0001542196,0.00008843259,0.00005438404],"domain_scores_gemma":[0.9992,0.0001416176,0.0002681899,0.0001543701,0.0001552924,0.00008045229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001133568,0.0001362097,0.7492675,0.0003661918,0.001017906,0.0003086033,0.0007271874,0.005068834,0.1279615,0.003671058,0.001909097,0.1084324],"study_design_scores_gemma":[0.00003131152,0.000299352,0.960341,0.00005944258,0.0005293539,0.0005914957,0.0005190382,0.01519015,0.006611877,0.01200285,0.00376864,0.00005554582],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9474581,0.00264018,0.03899917,0.0005870993,0.00002468209,0.0001610675,0.007409255,0.0001778011,0.002542678],"genre_scores_gemma":[0.9721069,0.0005614746,0.02325521,0.0001276911,0.00002700602,0.00006361015,0.003423768,0.00002219214,0.0004121638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002459333,"threshold_uncertainty_score":0.00691843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04344838880542878,"score_gpt":0.3371214831517113,"score_spread":0.2936730943462825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}