{"id":"W4309491159","doi":"10.1371/journal","title":"Drug repurposing for Chagas disease: In vitro assessment of nimesulide against Trypanosoma cruzi and insights on its mechanisms of action","year":2022,"lang":"pt","type":"article","venue":"Arca - Repositório Institucional da Fiocruz","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hakai Institute","keywords":"Trypanosoma cruzi; Chagas disease; Benznidazole; Drug; Nimesulide; Drug repositioning; Pharmacology; Repurposing; Nifurtimox; Medicine; Drug action; Biology; Virology; Parasite hosting; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003479278,0.0003263191,0.0006679772,0.0004240779,0.0002332782,0.0003913836,0.0002264357,0.0003338417,0.001447674],"category_scores_gemma":[0.0002875011,0.0001726613,0.0003710095,0.0002644523,0.0002360066,0.0002796286,0.0001967268,0.0004005828,0.0002637838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002935264,"about_ca_system_score_gemma":0.0003729926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001431668,"about_ca_topic_score_gemma":0.007564161,"domain_scores_codex":[0.9998271,0.00007323489,0.00001033546,0.00001896129,0.00004489791,0.00002547486],"domain_scores_gemma":[0.9999138,0.00002274857,0.00001451841,0.000008927964,0.00002208601,0.00001788506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009579738,0.0004173362,0.0007547622,0.0006427034,0.00005963717,0.0002734857,0.00007579142,0.0004568653,0.9556225,0.0004456086,0.0006084071,0.03968502],"study_design_scores_gemma":[0.000300275,0.01353216,0.01954542,0.0001143146,0.0003566094,0.001851234,0.0001883257,0.002503458,0.9262272,0.0003237234,0.03501352,0.00004371175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8211477,0.1605802,0.00361575,0.001606496,0.0002220838,0.0002650333,0.0006852003,0.00008081816,0.01179668],"genre_scores_gemma":[0.9570035,0.03458257,0.003050039,0.0002050859,0.00005615351,0.00004720858,0.0005067165,0.00001314952,0.004535579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001447674,"threshold_uncertainty_score":0.004842937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05271846540867775,"score_gpt":0.3467536545480765,"score_spread":0.2940351891393987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}