{"id":"W4309505073","doi":"10.1101/2022.11.18.517105","title":"A single extracellular loop of FoxA controls ligand specificity, uptake, and signaling in <i>Pseudomonas aeruginosa</i>","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University","keywords":"Siderophore; Pseudomonas aeruginosa; Extracellular; Biology; Ligand (biochemistry); Intracellular; Microbiology; Bacterial outer membrane; Cell biology; Transporter; Bacteria; Signal transduction; Antibiotics; Genetics; Receptor; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009194706,0.0001700484,0.0001727253,0.00008999014,0.0001816419,0.0002850599,0.0002232892,0.0002908649,0.0008715803],"category_scores_gemma":[0.0001506454,0.0001157371,0.0001566071,0.00005903642,0.0003265432,0.0001278773,0.0002015719,0.0003325009,0.0004371377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005323838,"about_ca_system_score_gemma":0.0002059805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001810177,"about_ca_topic_score_gemma":0.002028134,"domain_scores_codex":[0.9999366,0.000008568816,0.000003373794,0.00001582736,0.0000188262,0.00001687439],"domain_scores_gemma":[0.9999183,0.00002117698,0.00002306737,0.000006150721,0.000008000126,0.00002316609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008726876,0.00001407939,0.000349069,0.00001093362,0.000002595184,0.00006256517,0.00001325736,0.0001607465,0.9983968,0.000184413,0.00005736559,0.0006608733],"study_design_scores_gemma":[0.00003140851,0.00005672088,0.007974283,0.000009364458,0.000007796708,0.0002729247,0.00003595976,0.008047502,0.9807298,0.0001785291,0.002645187,0.00001041781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974146,0.0001883483,0.001499717,0.00005957543,0.00001069314,0.000003980582,0.00008501059,0.00006258945,0.000675449],"genre_scores_gemma":[0.9978343,0.00006579512,0.0009863811,0.00004643153,0.000004056557,0.000005111817,0.0001634108,0.00003378507,0.000860867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001810177,"threshold_uncertainty_score":0.003862739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277139799564479,"score_gpt":0.205602548203523,"score_spread":0.1928311502078782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}