{"id":"W4309506030","doi":"10.1080/15257770.2022.2148693","title":"Synthesis of 5’-fluorophosphate-modified short-interfering RNAs","year":2022,"lang":"en","type":"article","venue":"Nucleosides Nucleotides & Nucleic Acids","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ontario Institute of Technology","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Phosphoramidite; Nucleic acid; Small interfering RNA; Sense (electronics); Combinatorial chemistry; Chemistry; RNA; Oligonucleotide; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005403553,0.0007498354,0.0005331531,0.0003022101,0.0002993086,0.0003396024,0.0006960738,0.0005304567,0.001839136],"category_scores_gemma":[0.0005118372,0.0005755569,0.0005440387,0.0002417751,0.0002033591,0.0002915907,0.0003016761,0.0009983401,0.001843206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003296002,"about_ca_system_score_gemma":0.0003610652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000478739,"about_ca_topic_score_gemma":0.0008390425,"domain_scores_codex":[0.9996264,0.00006934822,0.00005827544,0.00008361849,0.000108934,0.0000534586],"domain_scores_gemma":[0.9997734,0.00005967289,0.00004404688,0.00004426578,0.00005202092,0.00002654069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003591432,0.00001038404,0.00002747516,0.00005738533,0.000006370392,0.00006224356,0.00002435019,0.0001763377,0.997311,0.0001829723,0.00007099062,0.002034624],"study_design_scores_gemma":[0.000007382263,0.00008912283,0.0001377961,0.000003402881,0.0000118472,0.00009662731,0.000005413639,0.0003526321,0.9946498,0.00003789364,0.00459861,0.000009463559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7378916,0.005786416,0.2334307,0.000398107,0.0005503977,0.001717207,0.004547126,0.002374187,0.01330433],"genre_scores_gemma":[0.7162017,0.004501957,0.2519037,0.0003122207,0.00009105539,0.001261151,0.00597831,0.0004689868,0.019281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001839136,"threshold_uncertainty_score":0.006152511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01294793125384066,"score_gpt":0.2382984450617311,"score_spread":0.2253505138078904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}