{"id":"W4309508403","doi":"10.15252/embr.202255420","title":"Composition, organization and mechanisms of the transition zone, a gate for the cilium","year":2022,"lang":"en","type":"review","venue":"EMBO Reports","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Cilium; Intraflagellar transport; Axoneme; Biology; Cell biology; Ciliopathy; Ciliopathies; Ciliogenesis; Endocytic cycle; Compartmentalization (fire protection); Membrane curvature; Transport protein; Endocytosis; Flagellum; Vesicle; Cell; Genetics; Biochemistry; Membrane; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001078805,0.001057715,0.001391039,0.001968853,0.0003675349,0.001934506,0.001526802,0.001938754,0.001282279],"category_scores_gemma":[0.0008294603,0.0005122112,0.0003071639,0.002398569,0.001986,0.002934355,0.001450527,0.002634722,0.001353143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001522667,"about_ca_system_score_gemma":0.001557096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0013649,"about_ca_topic_score_gemma":0.002039517,"domain_scores_codex":[0.9997527,0.00003305409,0.00003539672,0.00005779814,0.00009294,0.00002809519],"domain_scores_gemma":[0.9996833,0.0001187099,0.00005667348,0.00001514696,0.00007605332,0.00005011481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003331329,0.00004902702,0.0003221334,0.02172419,0.00009910845,0.0006221422,0.0001186285,0.001099283,0.01610572,0.02708292,0.05368435,0.8787594],"study_design_scores_gemma":[0.00002145934,0.00004622077,0.000824834,0.001330892,0.0000686534,0.001016768,0.00007321356,0.0001596201,0.001637071,0.007432192,0.9873579,0.00003126631],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001069635,0.9985458,0.0002288062,0.0004389452,0.0002813165,0.000002058556,0.00001652853,0.000006002202,0.0003737174],"genre_scores_gemma":[0.0007579061,0.9980572,0.0002284826,0.0002136604,0.0003063228,0.000004221123,0.00002917932,0.000001487439,0.0004016608],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001968853,"threshold_uncertainty_score":0.01104772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01293438915852241,"score_gpt":0.251299060186463,"score_spread":0.2383646710279406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}