{"id":"W4309510033","doi":"10.1002/brb3.2806","title":"Evidence of emerging BBB changes in mid‐age apolipoprotein E epsilon‐4 carriers","year":2022,"lang":"en","type":"article","venue":"Brain and Behavior","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"King Saud University; University of Sussex; Canadian Institute of Steel Construction; Alzheimer's Association","keywords":"Apolipoprotein E; Neuroimaging; Genotype; Blood–brain barrier; Population; Psychology; Magnetic resonance imaging; Medicine; Internal medicine; Oncology; Neuroscience; Disease; Biology; Genetics; Gene; Central nervous system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001998886,0.0001039348,0.0001737666,0.0001429331,0.0002403051,0.0000145194,0.0001337246,0.00002553795,0.000207496],"category_scores_gemma":[0.0002164041,0.00009952118,0.00003217263,0.0003478837,0.0001446852,0.00007662483,0.0002017064,0.0001710251,8.259274e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002469675,"about_ca_system_score_gemma":0.00001894571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002007465,"about_ca_topic_score_gemma":0.0002436465,"domain_scores_codex":[0.9989923,0.0001149297,0.0001573937,0.0002955706,0.0002427027,0.0001971414],"domain_scores_gemma":[0.9996032,0.0001137956,0.0000684986,0.0001536316,0.00001088563,0.00004997623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005757216,0.00004648808,0.01562669,0.00004438457,0.000002116072,0.00009780758,0.00374543,0.000004092795,0.9560968,0.0002886295,0.0005448954,0.02344507],"study_design_scores_gemma":[0.00177627,0.001114334,0.2613692,0.0001682786,0.0001073785,0.0001811157,0.01024626,0.00003528433,0.6947095,0.0004846458,0.02899689,0.0008107722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969617,0.0007060357,0.000004457173,0.001473933,0.0003666787,0.0002569277,0.00002701371,0.00002580118,0.000177465],"genre_scores_gemma":[0.9982561,0.00007411082,0.00005388045,0.0007466527,0.00002546148,0.0001886361,6.81501e-7,0.000009362503,0.0006450383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2613873,"threshold_uncertainty_score":0.4058356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07251199177758781,"score_gpt":0.3103469785109865,"score_spread":0.2378349867333986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}