{"id":"W4309510033","doi":"10.1002/brb3.2806","title":"Evidence of emerging BBB changes in mid‐age apolipoprotein E epsilon‐4 carriers","year":2022,"lang":"en","type":"article","venue":"Brain and Behavior","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"King Saud University; University of Sussex; Canadian Institute of Steel Construction; Alzheimer's Association","keywords":"Apolipoprotein E; Neuroimaging; Genotype; Blood–brain barrier; Population; Psychology; Magnetic resonance imaging; Medicine; Internal medicine; Oncology; Neuroscience; Disease; Biology; Genetics; Gene; Central nervous system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003945731,0.0002783378,0.0002681071,0.0008289816,0.0002611034,0.0005236896,0.0002816888,0.0005801915,0.002917401],"category_scores_gemma":[0.000981012,0.0001631993,0.0001468179,0.0003197284,0.0002827009,0.0003685364,0.0003287525,0.0003325142,0.0003815563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001075853,"about_ca_system_score_gemma":0.0001215791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001296588,"about_ca_topic_score_gemma":0.001123851,"domain_scores_codex":[0.9999207,0.0000121615,0.000009248702,0.00002133018,0.0000188991,0.0000175463],"domain_scores_gemma":[0.999129,0.0001161384,0.0004366373,0.00005044401,0.0001412517,0.000126539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004888286,0.0002845488,0.8769733,0.0001668827,0.0001475026,0.005631684,0.001380617,0.00004611326,0.09876434,0.0001929947,0.0002782415,0.01124541],"study_design_scores_gemma":[0.00001413818,0.0004889688,0.990469,0.00001825526,0.00004372878,0.005161933,0.0004081039,0.00007367913,0.002905986,0.0001503066,0.0002580853,0.00000774407],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991863,0.0002848567,0.0001381675,0.00002454133,0.000003162149,0.000004105584,0.00006415846,0.000005492982,0.0002891351],"genre_scores_gemma":[0.9992456,0.0001596274,0.0002189019,0.00002377734,0.00000515777,0.000004410421,0.00008200167,0.000002322183,0.0002582787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002917401,"threshold_uncertainty_score":0.009759724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07251199177758781,"score_gpt":0.3103469785109865,"score_spread":0.2378349867333986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}