{"id":"W4309513068","doi":"10.1038/s41598-022-23433-0","title":"Tridimensional cell culture of dermal fibroblasts promotes exosome-mediated secretion of extracellular matrix proteins","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôpital de l'Enfant-Jésus","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; McGill University; ALS Society of Canada; Génome Québec; Canada Research Chairs; Université Laval","keywords":"Cell biology; Extracellular matrix; Microvesicles; Paracrine signalling; Exosome; Fibroblast; Dermal fibroblast; Secretion; Dermis; Biology; Chemistry; Cell culture; microRNA; Biochemistry; Anatomy; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000951143,0.000168205,0.000201007,0.0001120909,0.0002166366,0.00002252005,0.0002216468,0.0001024988,0.0002564363],"category_scores_gemma":[0.0001652914,0.0001672441,0.0001950912,0.0003662031,0.0002793491,0.00001008249,0.000330989,0.0001362195,0.000003208306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000226299,"about_ca_system_score_gemma":0.0003492098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005209423,"about_ca_topic_score_gemma":0.000001331633,"domain_scores_codex":[0.9975162,0.0001547424,0.0006605292,0.0006869265,0.0007202607,0.0002613544],"domain_scores_gemma":[0.9981301,0.000009539881,0.0006889044,0.000811251,0.0002381681,0.0001220146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007839064,0.0004118514,0.001066851,0.0001325192,0.00002147275,0.000132803,0.0001778379,0.0007077577,0.9935401,0.00001788845,0.003655283,0.00005721087],"study_design_scores_gemma":[0.0003053079,0.0002546696,0.0001654921,0.00001965231,0.00002800557,0.0001798734,0.0001546487,0.0002547611,0.9821003,0.0003808303,0.01597924,0.0001772094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933542,0.004451954,0.0004380612,0.00002548965,0.0008106686,0.0006542787,0.00007171965,0.00001663603,0.0001769923],"genre_scores_gemma":[0.9903242,0.000005424399,0.002165764,0.000004500169,0.00004737599,0.00005791643,0.001358792,0.00002473309,0.006011305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01232396,"threshold_uncertainty_score":0.6820016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005426306761055525,"score_gpt":0.2227951453440887,"score_spread":0.2173688385830332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}