{"id":"W4309516979","doi":"10.1016/j.jbc.2022.102714","title":"Quantitative affinity measurement of small molecule ligand binding to major histocompatibility complex class-I–related protein 1 MR1","year":2022,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Agenzia Italiana del Farmaco, Ministero della Salute; Australian Research Council; National Institutes of Health; Australian Synchrotron; Australian Government; Australian Nuclear Science and Technology Organisation","keywords":"Major histocompatibility complex; Ligand (biochemistry); Chemistry; Ligand binding assay; Cell biology; Biology; Computational biology; Biochemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006023045,0.000826258,0.0004481167,0.0004085495,0.0002597428,0.0003947371,0.0005296054,0.0006814357,0.001532231],"category_scores_gemma":[0.0008817175,0.0002837378,0.0002701029,0.0003580441,0.0003387317,0.0003722422,0.0004329023,0.00117602,0.0005936725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004424236,"about_ca_system_score_gemma":0.0002038623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004444348,"about_ca_topic_score_gemma":0.000558209,"domain_scores_codex":[0.9990681,0.0003286588,0.00003682818,0.0001886447,0.0002293369,0.0001484991],"domain_scores_gemma":[0.9991702,0.0003454493,0.0001399202,0.0000576157,0.0001912242,0.00009565157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004292436,0.00001781587,0.0001191028,0.00003422032,0.00000598767,0.000007570893,0.00001281978,0.00007957102,0.9988499,0.00003789698,0.00001860947,0.0007736637],"study_design_scores_gemma":[0.000004149818,0.0002030091,0.0009937509,0.000003916138,0.000007912611,0.00004660841,0.0000187818,0.001955992,0.9963451,0.00002412873,0.0003916582,0.000004965081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9385039,0.002668185,0.05520294,0.0001396466,0.00004775832,0.0001154205,0.0003240035,0.0001847624,0.002813434],"genre_scores_gemma":[0.9550947,0.001939565,0.03564878,0.0001768171,0.00003118385,0.0002407009,0.0007895409,0.00004409766,0.006034619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001532231,"threshold_uncertainty_score":0.005125821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06972859219309815,"score_gpt":0.2631381485145013,"score_spread":0.1934095563214032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}