{"id":"W4309524984","doi":"10.21203/rs.3.rs-2269143/v1","title":"PREDICT validity for prognosis of breast cancer patients with pathogenic BRCA1/2 variants","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Syöpäsäätiö; European Commission; Fondation du cancer du sein du Québec; National Cancer Institute; National Institutes of Health; Government of Canada; Wellcome Trust; Canadian Institutes of Health Research; Sigrid Juséliuksen Säätiö; Genome Canada","keywords":"Breast cancer; Oncology; Cancer; Internal medicine; Medicine; Computational biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006754551,0.0008305372,0.0006554314,0.001769995,0.0004076674,0.001104254,0.0006102144,0.0006774372,0.001730775],"category_scores_gemma":[0.02320352,0.0002313917,0.0009832451,0.0007284151,0.0005322473,0.0006576371,0.001040612,0.0007216223,0.0005663054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003615177,"about_ca_system_score_gemma":0.000476689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001518618,"about_ca_topic_score_gemma":0.001581926,"domain_scores_codex":[0.9972045,0.001713635,0.000138257,0.0003188778,0.000413512,0.0002111178],"domain_scores_gemma":[0.9850855,0.009694107,0.002280319,0.001334511,0.0008413111,0.0007642799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004440604,0.00001814321,0.9959353,0.000006591722,0.000119938,0.00003629072,0.00002490386,0.0008130896,0.0001139047,0.00004003559,0.0001150742,0.002332562],"study_design_scores_gemma":[0.00004732553,0.0006872673,0.9670913,0.0000240945,0.0003235695,0.0005608766,0.0001634558,0.02866978,0.001032978,0.000912203,0.0004577439,0.00002946414],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972035,0.0001758572,0.001182748,0.0001122934,0.00001595049,0.00001047934,0.0005815942,0.00002586296,0.0006917485],"genre_scores_gemma":[0.9988371,0.00002883313,0.0003883087,0.00002046079,0.00001701205,0.000006339515,0.0005485823,0.000009699935,0.0001437364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006754551,"threshold_uncertainty_score":0.0357219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04845807993539698,"score_gpt":0.3720000230376061,"score_spread":0.3235419431022091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}