{"id":"W4309593277","doi":"10.1016/j.celrep.2022.111678","title":"Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Holland Bloorview Kids Rehabilitation Hospital; University of Manitoba; Health Canada; University of Toronto; University Health Network; SickKids Foundation; Hospital for Sick Children; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Neuron Nadační Fond Na Podporu Vědy; Ontario Brain Institute","keywords":"Biology; Gene; Autism; Genetics; Computational biology; Wnt signaling pathway; Proteomics; Autism spectrum disorder; Disease; Bioinformatics; Neuroscience; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003357682,0.0001621658,0.0002004905,0.00003042598,0.000357903,0.00001812469,0.0001001312,0.0001038196,0.00003136298],"category_scores_gemma":[0.00006870348,0.0001324191,0.000103422,0.00008782244,0.000156407,0.000002428631,0.0006533697,0.0001666545,7.148137e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007552901,"about_ca_system_score_gemma":0.00003047391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004942515,"about_ca_topic_score_gemma":6.860052e-7,"domain_scores_codex":[0.9986165,0.0001539671,0.0003538725,0.0004973728,0.0001363707,0.0002418879],"domain_scores_gemma":[0.9992311,0.00001355883,0.0003243846,0.0003266151,0.00002908908,0.00007525806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006467858,0.00008235839,0.0070103,0.00004937141,0.0000560503,0.0005805134,0.000102625,0.000426642,0.9868112,0.000136133,0.003188736,0.001491377],"study_design_scores_gemma":[0.001421405,0.002129754,0.3020267,0.0001952384,0.0002341605,0.000960395,0.003310125,0.0002259222,0.4441712,0.0426379,0.2005765,0.002110667],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9579424,0.04000317,0.0007458626,0.0001300863,0.0005181677,0.0003688061,0.00003810205,0.00003337468,0.0002199894],"genre_scores_gemma":[0.9920186,0.005952159,0.00109257,0.00003320522,0.00005879383,0.00007217351,0.00008354221,0.00001599347,0.0006729026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.54264,"threshold_uncertainty_score":0.5399896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01482770590956338,"score_gpt":0.207076552958772,"score_spread":0.1922488470492086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}