{"id":"W4309617441","doi":"10.1136/lupus-2022-000789","title":"Retinal toxicity in a multinational inception cohort of patients with systemic lupus on hydroxychloroquine","year":2022,"lang":"en","type":"article","venue":"Lupus Science & Medicine","topic":"Drug-Induced Ocular Toxicity","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital; Université Laval; University of Calgary; Dalhousie University; University of Toronto; University of Manitoba; Toronto Western Hospital; Centre for Advancing Health Outcomes; McGill University Health Centre","funders":"National Center for Research Resources; National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; National Center for Chronic Disease Prevention and Health Promotion; Versus Arthritis; Arthritis Research UK; Canadian Institutes of Health Research; National Institute for Health and Care Research; Wellcome Trust","keywords":"Medicine; Hydroxychloroquine; Toxicity; Internal medicine; Retinal; Cohort; Systemic lupus erythematosus; Univariate analysis; Cumulative dose; Body mass index; Cumulative incidence; Ophthalmology; Disease; Multivariate analysis; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001172921,0.0003810737,0.000409424,0.0006296763,0.0005804197,0.000880905,0.0005141736,0.0003546927,0.001425973],"category_scores_gemma":[0.002748717,0.0004039407,0.0005367422,0.0009453803,0.0002549923,0.0005178511,0.0005962492,0.0007612355,0.000217978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004697138,"about_ca_system_score_gemma":0.0004747731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01243395,"about_ca_topic_score_gemma":0.01188975,"domain_scores_codex":[0.9994955,0.0001243946,0.00003989121,0.0001545657,0.0001016946,0.00008383557],"domain_scores_gemma":[0.9973698,0.0003211725,0.00137018,0.0003256279,0.0002337949,0.0003795046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005628017,0.00001257588,0.9995112,0.000001388699,0.00001797927,0.00003292516,0.0000219513,0.00001073998,0.00006361767,0.000002777153,0.00002767765,0.0002408719],"study_design_scores_gemma":[0.00001148869,0.00008257914,0.9993032,0.000004251019,0.00002373419,0.0002757694,0.00005940866,0.0001278482,0.00002598037,0.000005433968,0.00007798828,0.000002179841],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994425,0.00009117017,0.00003762351,0.00002125023,0.000002638828,0.00000641276,0.0002621999,0.00000208162,0.0001340553],"genre_scores_gemma":[0.9991842,0.00008700613,0.00007332466,0.00003511284,0.00001234997,0.000008754184,0.0004683258,0.000002537782,0.0001283499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01243395,"threshold_uncertainty_score":0.02472317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009993593920788496,"score_gpt":0.2610572343716376,"score_spread":0.2510636404508491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}