{"id":"W4309617441","doi":"10.1136/lupus-2022-000789","title":"Retinal toxicity in a multinational inception cohort of patients with systemic lupus on hydroxychloroquine","year":2022,"lang":"en","type":"article","venue":"Lupus Science & Medicine","topic":"Drug-Induced Ocular Toxicity","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital; Université Laval; University of Calgary; Dalhousie University; University of Toronto; University of Manitoba; Toronto Western Hospital; Centre for Advancing Health Outcomes; McGill University Health Centre","funders":"National Center for Research Resources; National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; National Center for Chronic Disease Prevention and Health Promotion; Versus Arthritis; Arthritis Research UK; Canadian Institutes of Health Research; National Institute for Health and Care Research; Wellcome Trust","keywords":"Medicine; Hydroxychloroquine; Toxicity; Internal medicine; Retinal; Cohort; Systemic lupus erythematosus; Univariate analysis; Cumulative dose; Body mass index; Cumulative incidence; Ophthalmology; Disease; Multivariate analysis; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002268219,0.0002287092,0.0005416933,0.0007875959,0.000252572,0.000006844709,0.0003848828,0.00005046516,0.0002708636],"category_scores_gemma":[0.0007521358,0.0001718875,0.00004586223,0.00208553,0.0009558963,0.000195858,0.0001430904,0.000505743,0.000007977882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001221519,"about_ca_system_score_gemma":0.0003835285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001743476,"about_ca_topic_score_gemma":0.00004206074,"domain_scores_codex":[0.994944,0.0001288714,0.0006019411,0.0006683875,0.003200211,0.0004565283],"domain_scores_gemma":[0.998438,0.0001023687,0.0003452844,0.0005102984,0.000377873,0.0002261623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005968757,0.0006591292,0.961304,0.00007054899,0.00001100326,0.00004135277,0.001508665,0.0008291827,0.03366658,0.000213012,0.0001084476,0.0009912039],"study_design_scores_gemma":[0.007984618,0.003072801,0.9789696,0.0007287458,0.00006795649,0.0005617145,0.001121989,0.004280019,0.00269549,0.00003797837,0.0002378054,0.0002412265],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947672,0.0000400223,0.0000802666,0.0007293651,0.0009962525,0.001156031,0.00002075412,0.00004370344,0.002166427],"genre_scores_gemma":[0.9985975,0.000003888335,0.0001773539,0.0005092446,0.00009475758,0.00008582808,0.00008221214,0.00001959537,0.0004296337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03097109,"threshold_uncertainty_score":0.700937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009993593920788496,"score_gpt":0.2610572343716376,"score_spread":0.2510636404508491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}