{"id":"W4309656465","doi":"10.1158/2326-6066.cir-22-0260","title":"CD73 Inhibits cGAS–STING and Cooperates with CD39 to Promote Pancreatic Cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; Vector Institute; Hôpital de l'Enfant-Jésus; Université de Montréal; University of Toronto; University Health Network; Artificial Intelligence in Medicine (Canada); Centre Hospitalier de l’Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Cancer Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Université de Montréal; Terry Fox Research Institute","keywords":"Sting; Pancreatic cancer; Medicine; Cancer; Cancer research; Cancer immunotherapy; Immunotherapy; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008176183,0.0002663379,0.0001632835,0.0001626311,0.0001377871,0.0001776804,0.0001149028,0.0001434399,0.0008855593],"category_scores_gemma":[0.00007051375,0.00005917942,0.000171546,0.0001688123,0.0001206839,0.0001133648,0.0001133391,0.0003049451,0.0002173616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000282553,"about_ca_system_score_gemma":0.000277156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006149992,"about_ca_topic_score_gemma":0.001331743,"domain_scores_codex":[0.9999096,0.00001500366,0.000006849301,0.0000127005,0.0000232461,0.00003262568],"domain_scores_gemma":[0.9999717,0.000003485683,0.000006683789,0.00000458895,0.000002841417,0.00001063096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002132042,0.0001048948,0.0002843699,0.00003252434,0.00000690539,0.00007935418,0.000009984527,0.0001298189,0.9942915,0.0001455385,0.0001116178,0.004590321],"study_design_scores_gemma":[0.00003871805,0.000622256,0.003900547,0.000004545926,0.00001926285,0.0003415854,0.00001451571,0.001265302,0.9884815,0.00005287166,0.005256461,0.000002413485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957314,0.001553379,0.0008871902,0.00009046035,0.00002254512,0.00002466357,0.000142453,0.00005063411,0.001497322],"genre_scores_gemma":[0.9971696,0.000662605,0.0006119311,0.00002714974,0.000008683131,0.00001691395,0.0002157346,0.000005461201,0.001281859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008855593,"threshold_uncertainty_score":0.00296247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04895646800022256,"score_gpt":0.3561988983489186,"score_spread":0.307242430348696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}