{"id":"W4309656600","doi":"10.1111/pcmr.13076","title":"Genetically engineered multicistronic allele of <i>Pmel</i> yielding highly specific <scp>CreERT2‐</scp>mediated recombination in the melanocyte lineage","year":2022,"lang":"en","type":"article","venue":"Pigment Cell & Melanoma Research","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Centre for the Replacement Refinement and Reduction of Animals in Research; North West Cancer Research; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Medical Research Council; Medical Research Scotland; Medical Research Council Canada; Cancer Research UK","keywords":"Biology; Transgene; Melanocyte; Allele; Genetics; Cell biology; Gene; Melanoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002584774,0.0001883033,0.000208882,0.0002387217,0.0002311674,0.00004783739,0.0006952478,0.0001165931,0.0001263585],"category_scores_gemma":[0.0002004995,0.0001706619,0.00009721316,0.0004794646,0.00008778266,0.00000732796,0.0003297801,0.0004963404,0.0000243771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001270599,"about_ca_system_score_gemma":0.0001142446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005565004,"about_ca_topic_score_gemma":0.00002266161,"domain_scores_codex":[0.9965418,0.000873134,0.0004989126,0.0004867531,0.001012617,0.0005868012],"domain_scores_gemma":[0.9987063,0.000425842,0.0001207122,0.0005184627,0.0001398682,0.00008883233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009669372,0.0005397066,0.001945466,0.00005171262,0.00003370093,0.00002791347,0.0008395274,0.001032576,0.9857615,0.0003248605,0.008580334,0.0007660376],"study_design_scores_gemma":[0.002862544,0.001681444,0.006195277,0.00001507778,0.00001697328,0.0000139377,0.0033412,0.003081076,0.89544,0.0000799811,0.08710623,0.0001662616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917556,0.002037443,0.0005276047,0.0002031668,0.0001864284,0.0007898723,0.00003929779,0.00001123817,0.004449369],"genre_scores_gemma":[0.9959525,0.0009328994,0.0005909765,0.00006249684,0.0001436963,0.0002680584,0.0009093626,0.00003404098,0.001105974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09032147,"threshold_uncertainty_score":0.6959389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03334307061977904,"score_gpt":0.2893179186165143,"score_spread":0.2559748479967353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}