{"id":"W4309656600","doi":"10.1111/pcmr.13076","title":"Genetically engineered multicistronic allele of <i>Pmel</i> yielding highly specific <scp>CreERT2‐</scp>mediated recombination in the melanocyte lineage","year":2022,"lang":"en","type":"article","venue":"Pigment Cell & Melanoma Research","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Centre for the Replacement Refinement and Reduction of Animals in Research; North West Cancer Research; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Medical Research Council; Medical Research Scotland; Medical Research Council Canada; Cancer Research UK","keywords":"Biology; Transgene; Melanocyte; Allele; Genetics; Cell biology; Gene; Melanoma","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002182654,0.0005304903,0.000248943,0.0003345027,0.0002930964,0.0003805983,0.0004614864,0.0006012566,0.0030924],"category_scores_gemma":[0.00013704,0.0002679022,0.0003479417,0.0002255249,0.0003956201,0.0003262519,0.0004712253,0.001206686,0.002567271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002983942,"about_ca_system_score_gemma":0.0002933742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004084035,"about_ca_topic_score_gemma":0.0007666631,"domain_scores_codex":[0.9997554,0.00002487714,0.00002631091,0.00007612239,0.00006777093,0.00004941356],"domain_scores_gemma":[0.99979,0.00003375721,0.00007216175,0.00004020047,0.00002042791,0.00004354657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001166021,0.000009043491,0.00005755395,0.00002076219,0.000001596192,0.00006388169,0.00001080149,0.00002799771,0.9987754,0.0001696841,0.00006129672,0.000790273],"study_design_scores_gemma":[0.000008637826,0.00005687455,0.001120991,0.000006589989,0.000009143919,0.0004422689,0.00001387949,0.000416759,0.9904457,0.00003553353,0.007439012,0.000004546634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8752221,0.001263344,0.1033759,0.0005554704,0.0003411667,0.0004753333,0.004089486,0.002518342,0.01215875],"genre_scores_gemma":[0.9055815,0.001167381,0.04934612,0.0002386929,0.00004752522,0.0003174865,0.00610757,0.0006841964,0.03650954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0030924,"threshold_uncertainty_score":0.01034516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03334307061977904,"score_gpt":0.2893179186165143,"score_spread":0.2559748479967353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}