{"id":"W4309657771","doi":"10.1097/qad.0000000000003369","title":"Dolutegravir-containing HIV therapy reversibly alters mitochondrial health and morphology in cultured human fibroblasts and peripheral blood mononuclear cells","year":2022,"lang":"en","type":"article","venue":"AIDS","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health; Women's Health Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Mitochondrial toxicity; Dolutegravir; Peripheral blood mononuclear cell; Raltegravir; Telomerase reverse transcriptase; Pharmacology; Mitochondrion; Apoptosis; Mitochondrial ROS; Biology; Abacavir; Telomerase; Cancer research; Virology; Viral load; Cell biology; In vitro; Antiretroviral therapy; Human immunodeficiency virus (HIV); Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001241446,0.0001467242,0.0001571531,0.0001048159,0.0001399938,0.0003015018,0.0001184415,0.0001827245,0.001273283],"category_scores_gemma":[0.0001308783,0.00008160706,0.000127018,0.0001195733,0.0001328368,0.000127262,0.0001070559,0.000326438,0.0002448308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002048916,"about_ca_system_score_gemma":0.0001514912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001255996,"about_ca_topic_score_gemma":0.002630519,"domain_scores_codex":[0.9998771,0.00001432719,0.00001042352,0.00004285216,0.00003769502,0.00001769985],"domain_scores_gemma":[0.999953,0.00001058104,0.00001130384,0.000004850603,0.00001084071,0.000009308525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003769633,0.00009150813,0.001941913,0.00004588404,0.00001415789,0.00006403289,0.00006259964,0.000261279,0.9885062,0.00003684524,0.0000856136,0.008513015],"study_design_scores_gemma":[0.00005735655,0.001801759,0.04662844,0.0000158794,0.00003330689,0.0003445245,0.0001402061,0.004405135,0.9443396,0.00009921577,0.002124102,0.00001050249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949653,0.000782573,0.002462845,0.00006888241,0.00001292097,0.00002774446,0.0006450636,0.00004947693,0.0009851869],"genre_scores_gemma":[0.9939267,0.0005895189,0.002837555,0.00006090974,0.000004553881,0.00006048198,0.0006028087,0.000007442905,0.001910109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001273283,"threshold_uncertainty_score":0.004259527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01675582614478587,"score_gpt":0.2886783608829392,"score_spread":0.2719225347381534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}