{"id":"W4309658444","doi":"10.1038/s41589-022-01193-2","title":"A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins","year":2022,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Common Fund; York University; Vaccine Research Center; Frederick National Laboratory for Cancer Research; Leidos; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Cancer Prevention and Research Institute of Texas","keywords":"Neutralization; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; Biology; Coronavirus disease 2019 (COVID-19); Plasma protein binding; Virus; Medicine; Biochemistry; Infectious disease (medical specialty)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000297356,0.00051736,0.0003451198,0.0002131148,0.0002258979,0.0004465575,0.0002344019,0.0004044032,0.002919592],"category_scores_gemma":[0.0002645257,0.0001887323,0.0002867696,0.0001298069,0.0002166593,0.0002679014,0.0002996007,0.001049881,0.0005884172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001846063,"about_ca_system_score_gemma":0.0002805874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003883705,"about_ca_topic_score_gemma":0.0006829902,"domain_scores_codex":[0.9997786,0.00004003763,0.00001587668,0.0000248643,0.00005633759,0.00008434858],"domain_scores_gemma":[0.9999135,0.00002187829,0.00000684349,0.00001079918,0.00001477936,0.00003224687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002567212,0.0001491463,0.0001058734,0.00003652227,0.00001467117,0.0001157993,0.00002390408,0.0002414936,0.9925635,0.0003410857,0.0005687269,0.005582536],"study_design_scores_gemma":[0.0002516154,0.003653962,0.00478549,0.00001219199,0.00003079697,0.00148566,0.00005536918,0.001949969,0.9757472,0.0002777331,0.01173312,0.00001690392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760209,0.003234104,0.006952934,0.0005896876,0.0003244423,0.0001797932,0.0009185351,0.0003441435,0.01143549],"genre_scores_gemma":[0.9912645,0.0009322569,0.002337895,0.000289624,0.00006230433,0.00005090954,0.0008423023,0.00002074508,0.004199428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002919592,"threshold_uncertainty_score":0.009766996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03297584099600404,"score_gpt":0.3612411089475261,"score_spread":0.3282652679515221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}