{"id":"W4309658444","doi":"10.1038/s41589-022-01193-2","title":"A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins","year":2022,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Common Fund; York University; Vaccine Research Center; Frederick National Laboratory for Cancer Research; Leidos; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Cancer Prevention and Research Institute of Texas","keywords":"Neutralization; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; Biology; Coronavirus disease 2019 (COVID-19); Plasma protein binding; Virus; Medicine; Biochemistry; Infectious disease (medical specialty)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001422838,0.00009712375,0.0003120073,0.00007314725,0.00002595687,0.000001916585,0.0001387654,0.000312064,0.00001479151],"category_scores_gemma":[0.0002007828,0.00008175068,0.00005738954,0.0002454635,0.0002259763,0.00001510997,0.0001643601,0.000566459,9.83611e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005190581,"about_ca_system_score_gemma":0.0000957454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009179916,"about_ca_topic_score_gemma":0.000001610647,"domain_scores_codex":[0.9990927,0.00006230855,0.000224614,0.0002596264,0.0001698813,0.0001908435],"domain_scores_gemma":[0.999531,0.00008847082,0.00008588232,0.0001750498,0.0001001986,0.00001938623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004085575,0.0001499494,0.01057005,0.00007168404,0.00004950819,0.000006012969,0.00007168282,2.83751e-8,0.9837772,0.0006972788,0.002000446,0.002197586],"study_design_scores_gemma":[0.001278161,0.000328798,0.0007305805,0.00001153749,0.00002626653,0.00004146066,0.00002649971,0.00006583097,0.9380017,0.0003621451,0.05906015,0.0000668568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950434,0.0030728,0.00004009685,0.0006441473,0.00008561488,0.0001976322,0.0001197941,0.00001627495,0.0007802313],"genre_scores_gemma":[0.9863811,0.00001721178,0.00006282191,0.01338775,0.0000426229,0.00001382416,0.00007820489,0.000009998627,0.000006530351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0570597,"threshold_uncertainty_score":0.3333696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03297584099600404,"score_gpt":0.3612411089475261,"score_spread":0.3282652679515221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}