{"id":"W4309665367","doi":"10.1172/jci.insight.153740","title":"HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"Boston Nutrition Obesity Research Center, Boston University; School of Medicine, Duke University; National Institutes of Health; American Diabetes Association; American Heart Association; Université de Paris; Broad Institute; Institut National de la Santé et de la Recherche Médicale; National Institute of Diabetes and Digestive and Kidney Diseases; Stanley Center for Psychiatric Research, Broad Institute; Eli Lilly and Company; Centre National de la Recherche Scientifique","keywords":"Carbohydrate-responsive element-binding protein; Glucose homeostasis; Biology; Transcription factor; Homeostasis; Cell biology; Endocrinology; Genetics; Gene; Insulin resistance; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001891853,0.0003221127,0.0002614427,0.0005425952,0.0002718219,0.0004135293,0.0001686143,0.0002879954,0.003113299],"category_scores_gemma":[0.0001632641,0.0001554262,0.0002784299,0.0003122507,0.0003209741,0.000160322,0.0003758624,0.0006199025,0.0005232694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004009083,"about_ca_system_score_gemma":0.0003295339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00135645,"about_ca_topic_score_gemma":0.001976258,"domain_scores_codex":[0.9998161,0.00002017092,0.000008513432,0.00004673341,0.00006612823,0.00004242208],"domain_scores_gemma":[0.9998577,0.00001852228,0.00004284463,0.00001234871,0.00002363771,0.00004505808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002589233,0.00001065689,0.001292885,0.00006659708,0.00001196496,0.000129507,0.0000142297,0.0000843989,0.9937049,0.0002327772,0.0001915642,0.004001618],"study_design_scores_gemma":[0.00007092069,0.000272672,0.06289518,0.00002478986,0.00005695476,0.001606705,0.00008956542,0.001576231,0.9162011,0.0003404395,0.01683804,0.00002748438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9631169,0.006789608,0.01873916,0.000846192,0.0002429966,0.00006402282,0.003609266,0.0009613442,0.005630426],"genre_scores_gemma":[0.9806694,0.001838244,0.007110374,0.0003032589,0.00004547484,0.00003337463,0.001955082,0.00006406129,0.007980638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003113299,"threshold_uncertainty_score":0.01041502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02062131043970547,"score_gpt":0.2493269214647995,"score_spread":0.2287056110250941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}