{"id":"W4309667309","doi":"10.21203/rs.3.rs-2199652/v1","title":"Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"","keywords":"Antigen; Cell biology; Chemistry; Immunology; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002413573,0.0001842015,0.0003608766,0.0006333383,0.0003512842,0.00008013174,0.0002435013,0.0003852056,0.0002084073],"category_scores_gemma":[0.0003899393,0.0001827399,0.00004857074,0.0003100228,0.0003081528,0.0001729461,0.001069949,0.001486744,0.000005159456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006930322,"about_ca_system_score_gemma":0.0001687034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007464795,"about_ca_topic_score_gemma":0.00003476441,"domain_scores_codex":[0.9961168,0.002427923,0.0004385641,0.000422506,0.0001701443,0.0004240437],"domain_scores_gemma":[0.9985477,0.0007600869,0.0002099697,0.0003468516,0.00011877,0.00001659139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000551419,0.000123053,0.04949576,0.0003308276,0.0001047005,0.000002023768,0.006406646,0.00001656353,0.9400491,0.00008724425,0.0001135722,0.002719155],"study_design_scores_gemma":[0.0006258253,0.0001283243,0.4307953,0.000253223,0.000005532503,0.000005609287,0.002200053,0.000005787828,0.5647883,0.0001751137,0.0008913805,0.000125576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926901,0.005730738,0.000005125105,0.0001641237,0.0002332766,0.0009198493,0.00006794146,0.00002284103,0.0001659707],"genre_scores_gemma":[0.9961953,0.002815081,0.00005087843,0.000007431282,0.0000236941,0.0001245127,0.0001912775,0.00002388327,0.0005679922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3812995,"threshold_uncertainty_score":0.7451915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04400952841079137,"score_gpt":0.3432656269827553,"score_spread":0.2992560985719639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}