{"id":"W4309670946","doi":"10.1021/acsptsci.2c00160","title":"In Vitro Characterization of 6-Methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1<i>H</i>-indole (ZCZ011) at the Type 1 Cannabinoid Receptor: Allosteric Agonist or Allosteric Modulator?","year":2022,"lang":"en","type":"article","venue":"ACS Pharmacology & Translational Science","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of Otago","keywords":"Allosteric regulation; Allosteric modulator; Agonist; Chemistry; Pharmacology; Receptor; G protein-coupled receptor; Internalization; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001708252,0.0003729641,0.0003036422,0.0001346481,0.0001457566,0.000229785,0.0002691202,0.0002452738,0.001258484],"category_scores_gemma":[0.0001203657,0.0001526179,0.0002999087,0.0002011875,0.0001071338,0.0001344089,0.00009538344,0.0003919197,0.0008584069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002997992,"about_ca_system_score_gemma":0.000261628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001745538,"about_ca_topic_score_gemma":0.002888272,"domain_scores_codex":[0.9998938,0.00001864341,0.00000861937,0.00001825024,0.00002883945,0.00003183013],"domain_scores_gemma":[0.999956,0.000009206013,0.00001100645,0.000006178456,0.00001059513,0.000007066166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001035855,0.00003339111,0.00006870503,0.0000475003,0.000004396327,0.00003140381,0.000008778514,0.0001144366,0.9986796,0.00004378275,0.00005203765,0.0008123571],"study_design_scores_gemma":[0.00001791414,0.0003705849,0.001364697,0.000005518924,0.00002190572,0.0001673725,0.00001770704,0.0008319549,0.9948453,0.00002206479,0.002329518,0.000005423287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789279,0.00626649,0.008692721,0.0002536076,0.0000628353,0.00009780038,0.001717977,0.00009473644,0.003886028],"genre_scores_gemma":[0.9793881,0.004518713,0.005059225,0.0001383882,0.00002391792,0.00008582475,0.004235332,0.00003352689,0.006516958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001745538,"threshold_uncertainty_score":0.004210055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02208656222834377,"score_gpt":0.3230984741592902,"score_spread":0.3010119119309464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}