{"id":"W4309670946","doi":"10.1021/acsptsci.2c00160","title":"In Vitro Characterization of 6-Methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1<i>H</i>-indole (ZCZ011) at the Type 1 Cannabinoid Receptor: Allosteric Agonist or Allosteric Modulator?","year":2022,"lang":"en","type":"article","venue":"ACS Pharmacology & Translational Science","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of Otago","keywords":"Allosteric regulation; Allosteric modulator; Agonist; Chemistry; Pharmacology; Receptor; G protein-coupled receptor; Internalization; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001618993,0.000269818,0.000427125,0.0004142346,0.0008715278,0.00003587481,0.000729646,0.00009356882,0.004224507],"category_scores_gemma":[0.00005882589,0.000210039,0.0001206593,0.002871371,0.001219235,0.0003605541,0.000356126,0.0006426784,0.00004099321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006027971,"about_ca_system_score_gemma":0.002099265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001476277,"about_ca_topic_score_gemma":0.00003291701,"domain_scores_codex":[0.9960155,0.0003628485,0.0006462087,0.0007102883,0.001527251,0.0007379297],"domain_scores_gemma":[0.9987188,0.00007548818,0.0002392558,0.0003395355,0.0004142358,0.0002127131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003343193,0.000335684,0.001150404,0.00005103754,0.00004035476,0.00003505394,0.0009555765,0.000296516,0.9881018,0.00007250633,0.003712806,0.001905016],"study_design_scores_gemma":[0.003523814,0.0008408409,0.04103725,0.00001397097,0.000114311,0.0002156308,0.0001736732,0.00198336,0.8314776,0.0001026917,0.1201409,0.0003759541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9578492,0.0002918215,0.00001899355,0.03898937,0.001174054,0.001115717,0.0002092732,0.00003109877,0.0003204412],"genre_scores_gemma":[0.9884073,0.00009033848,0.0001187008,0.003976042,0.0002056104,0.000322303,0.0002509664,0.0000350497,0.006593691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1566242,"threshold_uncertainty_score":0.9966857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02208656222834377,"score_gpt":0.3230984741592902,"score_spread":0.3010119119309464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}