{"id":"W4309683849","doi":"10.3390/pharmaceutics14112520","title":"siRNA Functionalized Lipid Nanoparticles (LNPs) in Management of Diseases","year":2022,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"PEGylation; Small interfering RNA; Nanotechnology; RNA interference; Computational biology; Chemistry; Transfection; RNA; Biology; Materials science; Gene; Biochemistry; Polyethylene glycol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001169537,0.0002124653,0.0004434272,0.00008097984,0.00003154079,0.000008747875,0.0002886493,0.00007654807,0.0006214309],"category_scores_gemma":[0.000009876489,0.0002007113,0.000271378,0.0001650555,0.00004131894,0.000002286753,0.0002955432,0.0001283572,0.00002005032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003254171,"about_ca_system_score_gemma":0.00008303126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003107587,"about_ca_topic_score_gemma":0.000001031223,"domain_scores_codex":[0.998806,0.0001230286,0.0004032018,0.0003099091,0.000165348,0.0001925178],"domain_scores_gemma":[0.9994534,0.00002123752,0.0001675917,0.0002787413,0.00002077647,0.00005831141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007844975,0.0002567678,0.00004956025,0.007918806,0.0004967153,0.00002595923,0.000009738194,0.00003980279,0.0005517207,0.00005164145,0.002021907,0.9884989],"study_design_scores_gemma":[0.0003208495,0.00006185976,0.000007626078,0.000585944,0.0005539379,0.000006536784,0.00002829333,0.000008895729,0.0007152842,0.00001193812,0.9975014,0.0001974626],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001063755,0.9973871,0.000008985743,0.000006926712,0.000409667,0.0003206659,0.0001391084,0.000006769301,0.0006570087],"genre_scores_gemma":[0.0005989781,0.997282,0.00004224189,0.00005892438,0.0001025129,0.000147815,0.0004447485,0.00002780522,0.001294978],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9954795,"threshold_uncertainty_score":0.818477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1027433500458705,"score_gpt":0.3881437505114561,"score_spread":0.2854004004655856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}