{"id":"W4309683849","doi":"10.3390/pharmaceutics14112520","title":"siRNA Functionalized Lipid Nanoparticles (LNPs) in Management of Diseases","year":2022,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"PEGylation; Small interfering RNA; Nanotechnology; RNA interference; Computational biology; Chemistry; Transfection; RNA; Biology; Materials science; Gene; Biochemistry; Polyethylene glycol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001907688,0.0003292503,0.0002599531,0.0003302767,0.0001341373,0.0002621898,0.0002114682,0.0005655201,0.0005358671],"category_scores_gemma":[0.0001135645,0.0001170138,0.0001791326,0.0001874362,0.0002230228,0.0002843544,0.0003001238,0.0003546787,0.0003717912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000350321,"about_ca_system_score_gemma":0.0003236728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004887781,"about_ca_topic_score_gemma":0.0005238621,"domain_scores_codex":[0.9999067,0.00002251995,0.000008164902,0.00002155289,0.00002805809,0.00001308957],"domain_scores_gemma":[0.9999685,0.000007823339,0.000007470566,0.000001860334,0.000008501067,0.000005799304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002165003,0.0000574221,0.0003553845,0.001563358,0.00003627608,0.0006352577,0.0001041681,0.001656952,0.8694749,0.005881363,0.002319808,0.1176985],"study_design_scores_gemma":[0.000027877,0.0006385659,0.001067668,0.0001913228,0.00008818023,0.002000567,0.00006092224,0.003854363,0.8058913,0.002412715,0.1837314,0.00003505139],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1479388,0.7170084,0.1072146,0.003077223,0.0009319152,0.0001924928,0.000348415,0.0007168643,0.02257128],"genre_scores_gemma":[0.6024128,0.328647,0.04558211,0.001208841,0.0003844425,0.0001883936,0.0003471166,0.00009112336,0.02113824],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0005655201,"threshold_uncertainty_score":0.00254178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1027433500458705,"score_gpt":0.3881437505114561,"score_spread":0.2854004004655856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}