{"id":"W4309699822","doi":"10.3389/fragi.2022.1007098","title":"Sex differences in epigenetic age in Mediterranean high longevity regions","year":2022,"lang":"en","type":"article","venue":"Frontiers in Aging","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"dNaM; Centenarian; Longevity; Demography; Epigenetics; DNA methylation; Cellular Aging; Biological age; Successful aging; Biology; Gerontology; Medicine; Telomere; Physiology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004378114,0.0001184846,0.000193188,0.0002319801,0.00006426778,0.00001466134,0.0002164623,0.00006707082,0.0000144406],"category_scores_gemma":[0.0000438348,0.0001353217,0.00003680153,0.0002602657,0.00004958735,0.000003340631,0.0001604261,0.0002154993,3.994228e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007346725,"about_ca_system_score_gemma":0.00003662364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002511514,"about_ca_topic_score_gemma":0.0009117313,"domain_scores_codex":[0.9987361,0.0002442007,0.0002549918,0.0003472135,0.0001508907,0.0002665386],"domain_scores_gemma":[0.9996418,0.00001445305,0.00006027599,0.0002356858,0.000007190679,0.00004062484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002565138,0.00009623716,0.9653495,0.00001571104,0.000009509612,0.00006815486,0.00100116,0.002394184,0.01979634,0.00002274338,0.0003380218,0.0108828],"study_design_scores_gemma":[0.00176604,0.000237848,0.9545248,0.000054551,0.00001082145,0.000003177493,0.002179105,0.003218735,0.02260811,0.00798072,0.006827078,0.0005889756],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899597,0.003608587,0.00506556,0.0002251016,0.0006161992,0.0001706662,0.000007039921,0.000005717618,0.0003414922],"genre_scores_gemma":[0.9973081,0.0005388165,0.001566942,0.00007319362,0.0000778001,0.0000584053,0.00009516384,0.00001504525,0.0002665472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01082465,"threshold_uncertainty_score":0.5518259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0189220356070009,"score_gpt":0.245724979733501,"score_spread":0.2268029441265001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}