{"id":"W4309713572","doi":"10.1186/s13065-022-00893-z","title":"Synthesis, biological evaluation, and computational studies of some novel quinazoline derivatives as anticancer agents","year":2022,"lang":"en","type":"article","venue":"BMC Chemistry","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"Shiraz Transplant Research Center, Shiraz University of Medical Sciences","keywords":"Quinazolinone; Chemistry; Combinatorial chemistry; Docking (animal); Quinazoline; Cytotoxicity; Selectivity; Cell culture; Cancer cell lines; MTT assay; Stereochemistry; Lipinski's rule of five; Biochemistry; Cell growth; Cancer cell; In vitro; Cancer; Biology; In silico","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003052576,0.000154547,0.0002720302,0.00001694372,0.0002466287,0.0000103416,0.0001919893,0.0000530534,0.002684949],"category_scores_gemma":[0.0006326154,0.0001475378,0.00006863673,0.000102848,0.0002682831,0.00004089074,0.0002493432,0.0001211715,0.000002708156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009334587,"about_ca_system_score_gemma":0.0001504838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005810048,"about_ca_topic_score_gemma":3.434556e-7,"domain_scores_codex":[0.9987198,0.00002474422,0.0003433977,0.0003532686,0.0003985559,0.0001602329],"domain_scores_gemma":[0.9987771,0.0005653098,0.0002209882,0.00022019,0.0001613491,0.00005509986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000590231,0.0004704135,0.00873173,0.0003783462,0.0001896729,9.708515e-7,0.0003023873,0.00146698,0.9845422,0.002154867,0.000341203,0.00136221],"study_design_scores_gemma":[0.000963785,0.00001843154,0.008048811,0.00007538697,0.0001365914,0.0000432663,0.004304362,0.00536882,0.9699537,0.008398281,0.002295007,0.0003936041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959494,0.001669747,0.00007830095,0.0002338635,0.00001610051,0.00008904557,0.0001679566,0.00003360396,0.001761984],"genre_scores_gemma":[0.9976948,0.0001212742,0.001328885,0.00004866322,0.00009971416,0.0004078542,0.00007892661,0.00001382938,0.0002060344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01458854,"threshold_uncertainty_score":0.9982268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1070588051636585,"score_gpt":0.3626342194377109,"score_spread":0.2555754142740524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}