{"id":"W4309721238","doi":"10.3390/cells11233731","title":"Reduced SKP2 Expression Adversely Impacts Genome Stability and Promotes Cellular Transformation in Colonic Epithelial Cells","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"","keywords":"Biology; Carcinogenesis; Malignant transformation; Cancer research; Genome instability; Small interfering RNA; Cancer; Cell growth; Gene; SKP2; F-box protein; Cell biology; Ubiquitin ligase; Genetics; Ubiquitin; RNA; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007346751,0.0002604088,0.0001650016,0.000161144,0.0001383862,0.0003030835,0.0001108637,0.0001973919,0.001257639],"category_scores_gemma":[0.0000800277,0.00009679043,0.0001397145,0.0001624583,0.0001500168,0.0001230536,0.0001915491,0.0003434368,0.000379611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002499943,"about_ca_system_score_gemma":0.000224514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001057546,"about_ca_topic_score_gemma":0.001704088,"domain_scores_codex":[0.9999034,0.00001356605,0.000009190616,0.00001664139,0.0000349681,0.00002223761],"domain_scores_gemma":[0.9999475,0.000007498418,0.00001382177,0.000007442718,0.000006643661,0.00001697602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001229647,0.0000240414,0.0003669278,0.00003733719,0.000005406631,0.00007746817,0.000009911794,0.0001033179,0.9980389,0.0000817281,0.00009211724,0.001039859],"study_design_scores_gemma":[0.00002019466,0.0003971477,0.01181851,0.0000074444,0.00001903721,0.0004824077,0.0000678025,0.001907202,0.9799961,0.0000766991,0.005200633,0.000006856193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927966,0.001721978,0.001812628,0.0001830305,0.00003289807,0.00001478382,0.0008288557,0.0001299211,0.002479332],"genre_scores_gemma":[0.9960933,0.000741813,0.0005111609,0.00004484497,0.000003020301,0.00001674939,0.0006086464,0.00001232984,0.001968177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001257639,"threshold_uncertainty_score":0.004207194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01252831521464868,"score_gpt":0.2182222225049429,"score_spread":0.2056939072902942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}