{"id":"W4309721238","doi":"10.3390/cells11233731","title":"Reduced SKP2 Expression Adversely Impacts Genome Stability and Promotes Cellular Transformation in Colonic Epithelial Cells","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"","keywords":"Biology; Carcinogenesis; Malignant transformation; Cancer research; Genome instability; Small interfering RNA; Cancer; Cell growth; Gene; SKP2; F-box protein; Cell biology; Ubiquitin ligase; Genetics; Ubiquitin; RNA; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004441999,0.0001403022,0.0001389258,0.00004693002,0.0001389245,0.0000178426,0.0001349437,0.00009377804,0.0002199908],"category_scores_gemma":[0.00001220998,0.0001431675,0.00005468614,0.00008843951,0.00004844937,0.000008711236,0.0001155965,0.0001635561,0.000008924644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004445293,"about_ca_system_score_gemma":0.00009574964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001897785,"about_ca_topic_score_gemma":0.000007679176,"domain_scores_codex":[0.9988506,0.0002062204,0.0002275788,0.0003142523,0.0001381352,0.0002631987],"domain_scores_gemma":[0.9995718,0.00001232292,0.00007559755,0.0002258894,0.00002308585,0.0000913076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001511222,0.0001119788,0.00004173796,0.00006487993,0.000004981507,0.00000393345,0.001362412,0.0000630471,0.9979312,0.000004881312,0.00004125984,0.0002186013],"study_design_scores_gemma":[0.0007259363,0.0004607484,0.0001931969,0.000006764218,0.000006300847,0.000003715183,0.0003780854,0.00007714661,0.9890524,0.00006459821,0.008858868,0.000172307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978358,0.0005599728,0.00009230826,0.0000486298,0.0001306444,0.0006403183,0.0001726064,0.00001277378,0.0005069214],"genre_scores_gemma":[0.9992699,0.0001387637,0.0001474422,0.00005588221,0.00005538474,0.00007567322,0.0001608316,0.00001691279,0.00007923389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008878832,"threshold_uncertainty_score":0.5838202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01252831521464868,"score_gpt":0.2182222225049429,"score_spread":0.2056939072902942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}