{"id":"W4309731105","doi":"10.1016/j.ctarc.2022.100662","title":"A reduced dosing strategy can work for Alectinib in ALK rearranged non small cell lung cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Treatment and Research Communications","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Alectinib; Dosing; Lung cancer; Medicine; Cancer; Crizotinib; Oncology; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0003232388,0.0001624277,0.0002687875,0.0003054043,0.001302281,0.00005430276,0.0002328473,0.00005013289,0.0001267492],"category_scores_gemma":[0.00001814139,0.0001395815,0.00008045602,0.0008208368,0.0001426854,0.00004604876,0.000163903,0.0003731639,6.675963e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002354295,"about_ca_system_score_gemma":0.00160853,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01337432,"about_ca_topic_score_gemma":0.008402599,"domain_scores_codex":[0.9985228,0.0002375009,0.0002371816,0.0003453525,0.0002071085,0.0004500204],"domain_scores_gemma":[0.9984671,0.0003322054,0.00006572972,0.0007714047,0.0001927542,0.000170747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003418893,0.009027021,0.4738453,0.0008368339,0.002947897,0.00007405883,0.08274816,0.002338,0.03813153,0.0008413808,0.01847665,0.3673142],"study_design_scores_gemma":[0.0924567,0.01067004,0.340728,0.002975422,0.005241143,0.00007130412,0.05535157,0.01343934,0.01630603,0.001408729,0.4589548,0.00239698],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9181572,0.04720459,0.00001214509,0.01883204,0.0001274987,0.004620361,0.0003753389,0.00004931776,0.01062154],"genre_scores_gemma":[0.9625299,0.01169918,0.0006596172,0.00008877488,0.00007043618,0.01681578,0.0003121132,0.00003788951,0.007786316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4404781,"threshold_uncertainty_score":0.9999979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1455975808482045,"score_gpt":0.4736771517741957,"score_spread":0.3280795709259912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}