{"id":"W4309731105","doi":"10.1016/j.ctarc.2022.100662","title":"A reduced dosing strategy can work for Alectinib in ALK rearranged non small cell lung cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Treatment and Research Communications","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Alectinib; Dosing; Lung cancer; Medicine; Cancer; Crizotinib; Oncology; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006155763,0.0003384913,0.0006020049,0.0003710744,0.0003132883,0.001178475,0.0005868252,0.0007723667,0.007287421],"category_scores_gemma":[0.00182592,0.0001243722,0.0008626312,0.0002331719,0.0002471117,0.000828548,0.0003093801,0.001564052,0.001984036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006881003,"about_ca_system_score_gemma":0.0007914233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009961596,"about_ca_topic_score_gemma":0.002417641,"domain_scores_codex":[0.9996258,0.00008763521,0.00004215452,0.00006757867,0.0001169869,0.00005980878],"domain_scores_gemma":[0.9995893,0.0001126582,0.00008554644,0.00006936105,0.00007910628,0.00006408764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.004423018,0.002168193,0.005421479,0.0004789149,0.0005067937,0.0003354975,0.0000750266,0.004854016,0.05449174,0.00333878,0.0327538,0.8911527],"study_design_scores_gemma":[0.01030159,0.02651777,0.07488425,0.001121401,0.003237339,0.005003653,0.0004130662,0.02866869,0.1390353,0.02575662,0.6847202,0.000340207],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6496345,0.04616664,0.07806639,0.09327444,0.009069956,0.002341059,0.003886891,0.005369898,0.1121903],"genre_scores_gemma":[0.9315333,0.006664151,0.02619359,0.01203091,0.001421606,0.0004205016,0.00142959,0.0002600131,0.02004643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007287421,"threshold_uncertainty_score":0.02437884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1455975808482045,"score_gpt":0.4736771517741957,"score_spread":0.3280795709259912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}