{"id":"W4309764770","doi":"10.1016/j.jpba.2022.115178","title":"Imaged capillary isoelectric focusing (icIEF) tandem high resolution mass spectrometry for charged heterogeneity of protein drugs in biopharmaceutical discovery","year":2022,"lang":"en","type":"article","venue":"Journal of Pharmaceutical and Biomedical Analysis","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Advanced Electrophoresis Solutions (Canada)","funders":"","keywords":"Chemistry; Isoelectric focusing; Chromatography; Biopharmaceutical; Capillary electrophoresis; Mass spectrometry; Tandem mass spectrometry; Analytical Chemistry (journal)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007949834,0.0005745616,0.0003646291,0.001281458,0.0005729041,0.00104595,0.001033272,0.001110327,0.001466186],"category_scores_gemma":[0.001122672,0.0002437989,0.0002628947,0.0006704332,0.0004318649,0.001158994,0.0007435615,0.001571076,0.0004132452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001214273,"about_ca_system_score_gemma":0.0009364006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002218237,"about_ca_topic_score_gemma":0.003675132,"domain_scores_codex":[0.9993702,0.00007925626,0.00002153565,0.0001272508,0.0003232186,0.00007860874],"domain_scores_gemma":[0.9994305,0.0001677003,0.00008435379,0.00004544717,0.0002111363,0.00006086946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001246249,0.00004565314,0.0007421098,0.00006414217,0.00002155745,0.00008670551,0.00003897516,0.0002308133,0.9828023,0.001588706,0.0006849539,0.01356938],"study_design_scores_gemma":[0.00002229933,0.00008475087,0.003420811,0.00001422412,0.00002279208,0.0006137126,0.00004918026,0.01386961,0.9774137,0.0004649906,0.003993661,0.00003037945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7118945,0.01118564,0.2560992,0.001211514,0.0002776778,0.0003759887,0.001836655,0.002093865,0.01502512],"genre_scores_gemma":[0.8617669,0.003857844,0.1231011,0.001151033,0.0001123739,0.0002560829,0.001210659,0.0002297002,0.008314319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002218237,"threshold_uncertainty_score":0.008810163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01683972433334361,"score_gpt":0.3052159574898217,"score_spread":0.2883762331564781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}