{"id":"W4309770648","doi":"10.1016/j.crmeth.2022.100338","title":"Grabody B, an IGF1 receptor-based shuttle, mediates efficient delivery of biologics across the blood-brain barrier","year":2022,"lang":"en","type":"article","venue":"Cell Reports Methods","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"University of California, San Diego; National Institutes of Health; National Rehabilitation Center; Seoul National University","keywords":"Transferrin receptor; Insulin-like growth factor 1 receptor; Blood–brain barrier; Receptor; Antibody; Monoclonal antibody; Insulin-like growth factor; Pharmacology; Medicine; Immunology; Growth factor; Internal medicine; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002529139,0.0007918141,0.000279175,0.0004119898,0.0002061554,0.0003897892,0.0003708168,0.0005242482,0.001342212],"category_scores_gemma":[0.0001557979,0.0002007537,0.0002640452,0.0001468908,0.0003474982,0.000465611,0.0003517916,0.0006301564,0.0005982997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003800381,"about_ca_system_score_gemma":0.0002623581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003642776,"about_ca_topic_score_gemma":0.0004233951,"domain_scores_codex":[0.9998559,0.00002885049,0.000009832092,0.00003448818,0.0000405199,0.00003041122],"domain_scores_gemma":[0.9999177,0.00001457693,0.00003166307,0.000006247702,0.000008333325,0.00002142236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008008369,0.00001943496,0.00006314934,0.00006390841,0.000006620313,0.00004729415,0.000009811043,0.00008430723,0.995311,0.0004516053,0.0001350748,0.003727795],"study_design_scores_gemma":[0.00002895176,0.0003329995,0.000364392,0.000006072375,0.00001312111,0.0002934298,0.000009235922,0.0007406192,0.9925389,0.00006420025,0.005599833,0.000008172264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.81675,0.0147351,0.1547235,0.0006535592,0.000321924,0.0003713356,0.0009057322,0.002062845,0.009475992],"genre_scores_gemma":[0.9415931,0.004706537,0.04544807,0.0002121572,0.00003953997,0.0002145142,0.001049393,0.0001042844,0.006632437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001342212,"threshold_uncertainty_score":0.004490137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01742141379135198,"score_gpt":0.3218533258664588,"score_spread":0.3044319120751068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}