{"id":"W4309770648","doi":"10.1016/j.crmeth.2022.100338","title":"Grabody B, an IGF1 receptor-based shuttle, mediates efficient delivery of biologics across the blood-brain barrier","year":2022,"lang":"en","type":"article","venue":"Cell Reports Methods","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"University of California, San Diego; National Institutes of Health; National Rehabilitation Center; Seoul National University","keywords":"Transferrin receptor; Insulin-like growth factor 1 receptor; Blood–brain barrier; Receptor; Antibody; Monoclonal antibody; Insulin-like growth factor; Pharmacology; Medicine; Immunology; Growth factor; Internal medicine; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003224028,0.0002143974,0.0002526528,0.00004443524,0.0003058284,0.00002327581,0.0004117024,0.000141471,0.000258528],"category_scores_gemma":[0.000333621,0.0001589435,0.0002244994,0.0001683474,0.0002323064,0.000003155975,0.0003668809,0.0002176324,0.000001880891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001550959,"about_ca_system_score_gemma":0.0001824141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005277228,"about_ca_topic_score_gemma":0.000005572821,"domain_scores_codex":[0.9973609,0.0009534439,0.0005274974,0.000572857,0.0002363707,0.0003489604],"domain_scores_gemma":[0.9982311,0.0001634363,0.0004066625,0.0009231276,0.0001704439,0.0001052494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007711543,0.0002201432,0.002996736,0.00001456646,0.00004664791,0.00003180479,0.0002232907,0.004228541,0.9863879,0.000005045959,0.001247495,0.004520696],"study_design_scores_gemma":[0.0002175443,0.000783421,0.0005151306,0.000003771708,0.00003836497,0.0000424172,0.0008725953,0.0003736053,0.9482368,0.00006015466,0.04863501,0.0002211344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936041,0.001695368,0.002927214,0.00009350484,0.0008141352,0.0002404696,0.00007905484,0.00001841099,0.0005277852],"genre_scores_gemma":[0.9887069,0.00008246376,0.009030141,0.0006595691,0.0001406169,0.00008393919,0.0003454388,0.00002833962,0.000922629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04738752,"threshold_uncertainty_score":0.6481529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01742141379135198,"score_gpt":0.3218533258664588,"score_spread":0.3044319120751068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}