{"id":"W4309785809","doi":"10.3390/pharmaceutics14112516","title":"Plug and Pop: A 3D-Printed, Modular Platform for Drug Delivery Using Clinical Ultrasound and Microbubbles","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Metropolitan University; St. Michael's Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Microbubbles; Drug delivery; Ultrasound; In vivo; Biomedical engineering; Medicine; Dextran; Modular design; Nanotechnology; Computer science; Materials science; Radiology; Chemistry; Biotechnology; Chromatography; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003204556,0.0005982553,0.0003544835,0.000511141,0.0001451057,0.0004782155,0.0005144858,0.0006284446,0.00149667],"category_scores_gemma":[0.0004192712,0.0004030955,0.0004455164,0.0001670293,0.0003174816,0.0003534812,0.0004623569,0.0005176952,0.0008161254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001322577,"about_ca_system_score_gemma":0.0003022158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001357883,"about_ca_topic_score_gemma":0.0002081848,"domain_scores_codex":[0.9997544,0.00003675692,0.00001645217,0.00004450582,0.000116756,0.00003112975],"domain_scores_gemma":[0.9998292,0.00004455141,0.00004948356,0.00002495949,0.0000177471,0.00003405337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000107343,0.00004597202,0.0001222406,0.000118366,0.00001215601,0.0002983672,0.0000331742,0.00061634,0.986708,0.0002428434,0.0003222603,0.01137288],"study_design_scores_gemma":[0.00004054766,0.0005097351,0.001232779,0.000009687787,0.00003420504,0.0008730754,0.00001172753,0.003357185,0.9838995,0.0001293142,0.009869808,0.00003245701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.612204,0.003814897,0.3632208,0.0006808184,0.0005187409,0.0008776201,0.001616657,0.009237728,0.007828803],"genre_scores_gemma":[0.7953214,0.002622381,0.1897128,0.0004457559,0.000109947,0.0006797237,0.001173675,0.0005632164,0.009371117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00149667,"threshold_uncertainty_score":0.00500685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06553636282562254,"score_gpt":0.3270963340802803,"score_spread":0.2615599712546577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}