{"id":"W4309796921","doi":"10.1101/2022.11.22.517545","title":"MAP4K4 regulates biomechanical forces at adherens junctions and focal adhesions to promote collective cell migration","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Institute for Research in Immunology and Cancer","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Genentech; McGill University","keywords":"Adherens junction; Cell biology; Focal adhesion; Cell migration; Cell adhesion; Cadherin; Actin cytoskeleton; Adhesion; Actin; Biology; Regulator; Cytoskeleton; Cell; Phosphorylation; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000127718,0.0004646677,0.0002411903,0.0005204198,0.0002654203,0.000373358,0.0003017042,0.0003005656,0.002070201],"category_scores_gemma":[0.00014384,0.0002237639,0.0002789672,0.0002058535,0.0002873008,0.0002509685,0.0003350389,0.0003832479,0.0007302709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004714044,"about_ca_system_score_gemma":0.0002309542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007866346,"about_ca_topic_score_gemma":0.0005027635,"domain_scores_codex":[0.9998981,0.00001196474,0.000005782802,0.00001979149,0.00003043955,0.00003393634],"domain_scores_gemma":[0.9999129,0.000008767755,0.00002296378,0.00001342133,0.00001475604,0.00002715996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001194154,0.00002974383,0.0006860567,0.00003728457,0.000009561179,0.00008326952,0.000008801101,0.000392443,0.9968911,0.0003605316,0.0001181883,0.001263689],"study_design_scores_gemma":[0.00002775417,0.00006466426,0.01204996,0.000004553872,0.00001210076,0.0001522416,0.00002335645,0.004702787,0.9807717,0.0003170326,0.00186713,0.000006772895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905711,0.0008356289,0.005405405,0.0001581292,0.00003241822,0.00001885363,0.0003087723,0.000176652,0.002493022],"genre_scores_gemma":[0.9934444,0.0002663879,0.002056878,0.00001835148,0.000009187528,0.00002708316,0.0002410932,0.00003682793,0.003899733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002070201,"threshold_uncertainty_score":0.006925464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01068129286500842,"score_gpt":0.2204623076733293,"score_spread":0.2097810148083208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}