{"id":"W4309838597","doi":"10.1161/jaha.122.027958","title":"Flow‐Induced Secretion of Endothelial Heparanase Regulates Cardiac Lipoprotein Lipase and Changes Following Diabetes","year":2022,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Diabetes mellitus; Lipoprotein lipase; Heparanase; Secretion; Internal medicine; Endocrinology; Cardiology; Adipose tissue; Heparin; Heparan sulfate","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001480861,0.0001810828,0.0001896053,0.0001984917,0.0001053379,0.000285488,0.00009862654,0.0002373583,0.001096432],"category_scores_gemma":[0.0001446815,0.0001280194,0.0002780416,0.0001304976,0.0002026292,0.0002220576,0.0001330484,0.0005803049,0.0001605913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000279992,"about_ca_system_score_gemma":0.0001015429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003723296,"about_ca_topic_score_gemma":0.0003393201,"domain_scores_codex":[0.9999093,0.00001364437,0.00001019624,0.00001893866,0.00001473096,0.00003313],"domain_scores_gemma":[0.9998827,0.00001283852,0.00003346901,0.00000932606,0.00001559823,0.00004601484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001351818,0.0001150197,0.002537886,0.00003586035,0.00001008097,0.0001702145,0.00003590785,0.00002343524,0.993548,0.00006976123,0.00006765321,0.002034354],"study_design_scores_gemma":[0.0001262702,0.001162649,0.2570871,0.0000178077,0.00006229417,0.0006534064,0.0002315136,0.001145334,0.7377468,0.000211272,0.001535485,0.00002005104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982415,0.0006889606,0.0003607705,0.00006249182,0.00001904647,0.00001183858,0.0001576799,0.00001349687,0.0004440921],"genre_scores_gemma":[0.9979091,0.0004736502,0.000355777,0.00006859718,0.0000149309,0.00003496274,0.000209249,0.000005099034,0.0009286373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001096432,"threshold_uncertainty_score":0.003667891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008830866494011219,"score_gpt":0.2378095771443047,"score_spread":0.2289787106502935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}