{"id":"W4309839607","doi":"10.3390/brainsci12121596","title":"Cannabinoids in Late Life Parkinson’s Disease and Dementia: Biological Pathways and Clinical Challenges","year":2022,"lang":"en","type":"review","venue":"Brain Sciences","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Instituto Nacional de Biomarcadores em Neuropsiquiatria; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Cannabidiol; Neuroprotection; Medicine; Dementia; Disease; Cannabinoid; Parkinson's disease; Clinical trial; Synthetic cannabinoids; Adverse effect; Cannabis; Psychiatry; Pharmacology; Neuroscience; Psychology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004374393,0.000327257,0.001340567,0.0003756549,0.0002706765,0.0000940609,0.0003354001,0.0002224371,0.0002599205],"category_scores_gemma":[0.002156386,0.0002137641,0.0002599538,0.0005547687,0.00148177,0.00007103893,0.0006318478,0.0007427756,0.00000467514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006445032,"about_ca_system_score_gemma":0.001747456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006382585,"about_ca_topic_score_gemma":0.00007285347,"domain_scores_codex":[0.9961777,0.0007455345,0.0007242339,0.001146924,0.000638689,0.0005669234],"domain_scores_gemma":[0.9984122,0.0002836808,0.0001748252,0.0002953787,0.0000270417,0.0008068758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002781069,0.0001497847,0.003478192,0.002841888,0.00006375936,0.0002261091,0.00008818606,1.206121e-7,1.497577e-7,0.0004786257,0.006528333,0.9861171],"study_design_scores_gemma":[0.0003845723,0.0006032341,0.02805646,0.0009353101,0.0001538618,0.00002860105,0.0001711932,0.0000303524,1.495621e-8,0.0001995462,0.9691936,0.0002432654],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007398047,0.9766926,2.654236e-7,0.01413366,0.000179908,0.0009242179,0.00004814942,0.00002925187,0.0005939308],"genre_scores_gemma":[0.0005842791,0.9976937,0.00002954478,0.0006145154,0.0002095396,0.0002870389,0.00002200274,0.00001881636,0.0005405938],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9858738,"threshold_uncertainty_score":0.8717046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2406531928984162,"score_gpt":0.4218517131033504,"score_spread":0.1811985202049342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}