{"id":"W4309839607","doi":"10.3390/brainsci12121596","title":"Cannabinoids in Late Life Parkinson’s Disease and Dementia: Biological Pathways and Clinical Challenges","year":2022,"lang":"en","type":"review","venue":"Brain Sciences","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Instituto Nacional de Biomarcadores em Neuropsiquiatria; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Cannabidiol; Neuroprotection; Medicine; Dementia; Disease; Cannabinoid; Parkinson's disease; Clinical trial; Synthetic cannabinoids; Adverse effect; Cannabis; Psychiatry; Pharmacology; Neuroscience; Psychology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001541954,0.000642601,0.001336696,0.00114105,0.000880212,0.002113219,0.0009329186,0.003096551,0.002560233],"category_scores_gemma":[0.001712712,0.0002195157,0.0006286582,0.0008492367,0.001844079,0.003538582,0.001449641,0.004013342,0.001121051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001754972,"about_ca_system_score_gemma":0.003062335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002794774,"about_ca_topic_score_gemma":0.004703722,"domain_scores_codex":[0.9995573,0.0001308235,0.00007138459,0.00007483967,0.0001023853,0.00006331512],"domain_scores_gemma":[0.9987772,0.0004695949,0.0001580362,0.00004766796,0.0003532314,0.0001942703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008464914,0.0003957972,0.005758146,0.005445425,0.0001637781,0.003843047,0.0006794609,0.0004220472,0.003746852,0.03478351,0.05048346,0.8934319],"study_design_scores_gemma":[0.0002072754,0.001032038,0.01911062,0.01054136,0.0004640508,0.02261337,0.004115197,0.001476545,0.002032863,0.1422507,0.7959496,0.0002063976],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002327913,0.9690329,0.0004225225,0.02547099,0.0006083141,0.000009429177,0.00004213522,0.00001822431,0.002067438],"genre_scores_gemma":[0.03195429,0.9497788,0.001776041,0.009455053,0.005008226,0.00005857915,0.00008760633,0.000009626248,0.001871736],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003096551,"threshold_uncertainty_score":0.01273328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2406531928984162,"score_gpt":0.4218517131033504,"score_spread":0.1811985202049342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}