{"id":"W4309842478","doi":"10.3389/fphar.2022.1062495","title":"R-carvedilol, a potential new therapy for Alzheimer’s disease","year":2022,"lang":"en","type":"review","venue":"Frontiers in Pharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research; Krembil Foundation; Heart and Stroke Foundation of Canada","keywords":"Carvedilol; Neuroscience; Disease; Medicine; Amyloid (mycology); Alzheimer's disease; Memory impairment; Pharmacology; Internal medicine; Biology; Pathology; Heart failure; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003024868,0.0006747529,0.0009172024,0.001536283,0.0002169803,0.0005802764,0.000616645,0.0007353756,0.003045256],"category_scores_gemma":[0.0003157059,0.0001739359,0.0003409651,0.0009712078,0.0003299431,0.0008898053,0.0005081795,0.00204176,0.002707359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003999513,"about_ca_system_score_gemma":0.0005541869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008658638,"about_ca_topic_score_gemma":0.001680416,"domain_scores_codex":[0.9999254,0.00001113967,0.0000089586,0.00001754713,0.00002815506,0.000008841741],"domain_scores_gemma":[0.9999062,0.00003686252,0.00001317104,0.000003741465,0.00002651165,0.00001363626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001280123,0.0001145605,0.00009431883,0.01069528,0.00006516666,0.0002134663,0.00004933931,0.0002830127,0.005606104,0.004807751,0.03296199,0.944981],"study_design_scores_gemma":[0.00003411423,0.0001368715,0.0004878381,0.001198958,0.00006806349,0.0009167801,0.00002858651,0.00006983597,0.0007922782,0.001852031,0.9944,0.00001479082],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002386226,0.9973453,0.0001768383,0.0003145316,0.000234622,0.000008790395,0.00003588659,0.00001540736,0.001630107],"genre_scores_gemma":[0.0009976658,0.9971395,0.0002240907,0.0002569652,0.000159701,0.000009127015,0.0000500139,0.000002415885,0.00116054],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003045256,"threshold_uncertainty_score":0.01018739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1997903346949747,"score_gpt":0.4444074866773828,"score_spread":0.244617151982408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}