{"id":"W4309857519","doi":"10.3389/fnagi.2022.1038343","title":"Evidence of Filamin A loss of solubility at the prodromal stage of neuropathologically-defined Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Centre hospitalier de l'Université Laval; Université du Québec à Montréal; Université de Montréal; Université Laval; Montreal Neurological Institute and Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health","keywords":"Filamin; Disease; Prodromal Stage; Stage (stratigraphy); Neuroscience; Medicine; Psychology; Pathology; Dementia; Chemistry; Biology; Biochemistry; Cytoskeleton","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001913371,0.0002501379,0.0001502069,0.0008404151,0.0003130074,0.0002825161,0.0002097005,0.0002681625,0.002221088],"category_scores_gemma":[0.0004313738,0.0001294831,0.0001469812,0.0002782797,0.0002552974,0.0001821937,0.0002467941,0.0002788704,0.0002795284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000188296,"about_ca_system_score_gemma":0.0001171363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00229053,"about_ca_topic_score_gemma":0.002107945,"domain_scores_codex":[0.9999352,0.000007431661,0.000009012194,0.0000183249,0.0000174843,0.00001248914],"domain_scores_gemma":[0.9995458,0.00004342472,0.0002070947,0.00003638438,0.00007932971,0.00008794617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002946069,0.0001575594,0.7878301,0.00008245213,0.0001283305,0.002077091,0.0004800847,0.00005193242,0.1997011,0.00006917251,0.0001674059,0.006308686],"study_design_scores_gemma":[0.00001151573,0.0003017645,0.9898948,0.000004505855,0.00002631704,0.002137347,0.0001549796,0.0000953186,0.007163248,0.0000327649,0.0001741114,0.000003345329],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993457,0.0002128963,0.00007223342,0.000008513422,0.000001878946,0.000003973831,0.00009638064,0.000004013915,0.0002544047],"genre_scores_gemma":[0.9995446,0.00005016734,0.00008178156,0.000005221792,0.000002574929,0.0000024121,0.000128745,0.000001325925,0.0001832003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00229053,"threshold_uncertainty_score":0.007430255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06867914393488968,"score_gpt":0.3272079882031863,"score_spread":0.2585288442682966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}