{"id":"W4309858727","doi":"10.1111/acel.13741","title":"Neuronal <scp>HLH</scp>‐30/<scp>TFEB</scp> modulates peripheral mitochondrial fragmentation to improve thermoresistance in <i>Caenorhabditis elegans</i>","year":2022,"lang":"en","type":"article","venue":"Aging Cell","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Moncton","funders":"National Institute on Aging; National Institutes of Health; New Brunswick Innovation Foundation; Fondation Jean-Louis Lévesque; Fondation de la recherche en santé du Nouveau-Brunswick","keywords":"TFEB; Biology; Caenorhabditis elegans; Cell biology; Autophagy; Mutant; Transcription factor; Transcriptome; Genetics; Gene; Gene expression; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007474487,0.0002677157,0.0001859614,0.0001264108,0.0001736489,0.0002017295,0.0002168817,0.0002520386,0.001320305],"category_scores_gemma":[0.00005898824,0.00009573198,0.0002116592,0.00007669536,0.0002482578,0.0001570201,0.0001977429,0.0005974592,0.0003489095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003655961,"about_ca_system_score_gemma":0.0002437952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002023085,"about_ca_topic_score_gemma":0.004640575,"domain_scores_codex":[0.9999293,0.000003601226,0.000006380748,0.00002191987,0.00001904072,0.00001968099],"domain_scores_gemma":[0.9999424,0.000004512875,0.00001606194,0.000005872594,0.000007641314,0.00002343146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003785322,0.000009714237,0.00006926102,0.00002128519,0.000002280894,0.0000217607,0.000003762291,0.00002864205,0.9992649,0.00003034934,0.00003811898,0.000472118],"study_design_scores_gemma":[0.00001542816,0.0001104329,0.007282431,0.000008622204,0.00001345502,0.0001034036,0.00002792268,0.0009221337,0.9891524,0.00003688041,0.002320111,0.000006743242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946001,0.0006873782,0.001900834,0.0001082142,0.00003188734,0.0000262493,0.001054903,0.0001309913,0.001459495],"genre_scores_gemma":[0.992363,0.0004876454,0.002144814,0.0001088069,0.000006488203,0.00004481785,0.0008808704,0.00006159946,0.003901997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002023085,"threshold_uncertainty_score":0.004416823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004312242697587944,"score_gpt":0.2027273198556389,"score_spread":0.1984150771580509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}