{"id":"W4309866766","doi":"10.1212/nxi.0000000000200062","title":"Association of Vitamin D Polygenic Risk Scores and Disease Outcome in People With Multiple Sclerosis","year":2022,"lang":"en","type":"review","venue":"Neurology Neuroimmunology & Neuroinflammation","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of Mental Health; Canadian Institutes of Health Research; Biogen; Amgen","keywords":"Vitamin D and neurology; Expanded Disability Status Scale; Genome-wide association study; Mendelian randomization; Confounding; Multiple sclerosis; Medicine; Internal medicine; Observational study; Oncology; Genetics; Single-nucleotide polymorphism; Biology; Immunology; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001860431,0.000617301,0.002383551,0.002631142,0.0001547895,0.000713859,0.0007352088,0.0007527876,0.002256802],"category_scores_gemma":[0.004590927,0.000229975,0.001605852,0.00264236,0.0003066346,0.0004529918,0.0004545297,0.0006538928,0.0002700926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005638513,"about_ca_system_score_gemma":0.001394947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003843478,"about_ca_topic_score_gemma":0.00487894,"domain_scores_codex":[0.9992602,0.0002868176,0.0001558939,0.0001073777,0.0001650847,0.00002447793],"domain_scores_gemma":[0.9981176,0.001384902,0.000282263,0.0000307112,0.0001545276,0.00003010711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0004477752,0.00004239072,0.003151152,0.1505511,0.005282022,0.00009770609,0.00007407385,0.000300109,0.0002403076,0.001359304,0.006885889,0.8315683],"study_design_scores_gemma":[0.0009361869,0.001054774,0.07565336,0.3168498,0.06066853,0.005546094,0.0004732504,0.0008628721,0.001364605,0.00714029,0.5292464,0.000203704],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002188867,0.9994842,0.00003318537,0.00008573305,0.00002510984,0.00000507482,0.0000287917,0.000001576816,0.0001173554],"genre_scores_gemma":[0.00336629,0.9963,0.0001296161,0.00006275919,0.00003066855,0.00001327161,0.00004132824,6.637122e-7,0.00005532613],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003843478,"threshold_uncertainty_score":0.009838998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05437899373133189,"score_gpt":0.2984337808973357,"score_spread":0.2440547871660038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}