{"id":"W4309889913","doi":"10.1038/s41698-022-00328-x","title":"MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK suppression","year":2022,"lang":"en","type":"article","venue":"npj Precision Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Japanese Respiratory Society; National Cancer Institute; BC Cancer Foundation; Government of Canada; Michael Smith Health Research BC; Memorial Sloan-Kettering Cancer Center; Eli Lilly and Company","keywords":"Trametinib; KRAS; MEK inhibitor; MAPK/ERK pathway; Cancer research; Drug resistance; Mutant; Adenocarcinoma; Medicine; Cancer; Biology; Kinase; Internal medicine; Gene; Genetics; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001086172,0.000155018,0.0001815707,0.0003828961,0.0001399321,0.0002648603,0.0001271191,0.0001995418,0.001023738],"category_scores_gemma":[0.0001865227,0.000111058,0.000187899,0.0002124644,0.0001653916,0.00009948316,0.0001926855,0.0003039333,0.0002241294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001609054,"about_ca_system_score_gemma":0.00009240105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003338722,"about_ca_topic_score_gemma":0.0005072341,"domain_scores_codex":[0.999911,0.00001549061,0.00001285074,0.00001671965,0.0000248377,0.00001916713],"domain_scores_gemma":[0.9998099,0.000033125,0.0000712489,0.00002196923,0.00001974375,0.00004396816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006935101,0.0001452237,0.1109533,0.00004028834,0.0000273012,0.003200586,0.00003871234,0.0002244661,0.8773155,0.0001890714,0.0001212325,0.00705088],"study_design_scores_gemma":[0.00003558763,0.002053363,0.6833306,0.00001013526,0.0000701332,0.04695414,0.0001640886,0.00445478,0.2604624,0.0003123076,0.002131402,0.000021115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992354,0.00015866,0.0002233697,0.00001837471,0.000001317076,0.000005048118,0.00004365227,0.00001675759,0.0002974245],"genre_scores_gemma":[0.9996212,0.00005213347,0.0001361481,0.000007494712,0.000001110113,0.0000018015,0.00005050613,0.000001964476,0.0001277826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001023738,"threshold_uncertainty_score":0.003424764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00917306857849693,"score_gpt":0.2587210472632028,"score_spread":0.2495479786847059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}