{"id":"W4309905701","doi":"10.21203/rs.3.rs-2275247/v1","title":"Safety and Efficacy of First-in-Man Intrathecal Transplantation of Human Astrocytes (AstroRx) in ALS Patients: Phase I/IIa Clinical Trial Results","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kootenay Association for Science & Technology","funders":"","keywords":"Intrathecal; Transplantation; Medicine; Clinical trial; Internal medicine; Intensive care medicine; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001778623,0.001305541,0.001536252,0.0002721012,0.0004442112,0.0009859881,0.0006326076,0.001463205,0.002183659],"category_scores_gemma":[0.000539172,0.0003155431,0.0009522902,0.0002745452,0.0008030656,0.0005743749,0.0002489188,0.002479691,0.0006722157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004665006,"about_ca_system_score_gemma":0.0008402566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004835906,"about_ca_topic_score_gemma":0.0008387347,"domain_scores_codex":[0.9996363,0.0001901098,0.00002389327,0.00005819304,0.00003039515,0.00006102453],"domain_scores_gemma":[0.9995552,0.00006836932,0.0001098018,0.00004189405,0.00004281406,0.0001820147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6107467,0.1082994,0.004281386,0.00201981,0.001511441,0.0004168353,0.0005177576,0.003329957,0.1551325,0.0003969617,0.004159543,0.1091877],"study_design_scores_gemma":[0.1917599,0.7875159,0.005904197,0.00007355085,0.0003538109,0.0002577896,0.00006819125,0.0009068215,0.01089577,0.0001377646,0.002099677,0.00002666504],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919724,0.002913701,0.0008190236,0.0002972432,0.000104962,0.001844166,0.0006730567,0.00009419917,0.001281128],"genre_scores_gemma":[0.9914425,0.002018344,0.001259751,0.0005147537,0.0001390919,0.001729815,0.001050979,0.00002082068,0.001823839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002183659,"threshold_uncertainty_score":0.009406328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1332043506075471,"score_gpt":0.4909721828451593,"score_spread":0.3577678322376122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}