{"id":"W4309908954","doi":"10.1101/2022.11.24.517842","title":"Autolysosomal exocytosis of lipids protect neurons from ferroptosis","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"NIH Office of the Director; Office of Strategic Coordination; National Institutes of Health; National Institute on Aging; University of Alberta; Office of Research Infrastructure Programs, National Institutes of Health; Canadian Institutes of Health Research; Alzheimer Society; Texas Children's Hospital; BrightFocus Foundation; Howard Hughes Medical Institute","keywords":"Exocytosis; Cell biology; Oxidative stress; Lipid peroxidation; Protein aggregation; Programmed cell death; Biology; Membrane lipids; Chemistry; Biochemistry; Apoptosis; Secretion; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002131865,0.0002621503,0.0002398586,0.0002322185,0.0001665003,0.0002671385,0.0002066271,0.0003131895,0.0016983],"category_scores_gemma":[0.0001551211,0.00008768676,0.0001800666,0.00009332784,0.0002353415,0.0002807817,0.000248943,0.0004282646,0.000736418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002440096,"about_ca_system_score_gemma":0.0001665973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002417788,"about_ca_topic_score_gemma":0.0003155004,"domain_scores_codex":[0.9999328,0.000008625602,0.00000740452,0.00001386229,0.0000238534,0.00001350917],"domain_scores_gemma":[0.999899,0.0000188569,0.00002302368,0.00002212781,0.00001872283,0.00001820444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001361279,0.0000165515,0.0003638622,0.00004972097,0.00000801013,0.0001372787,0.00001777378,0.00009490278,0.9970078,0.0003380614,0.0002109198,0.001619083],"study_design_scores_gemma":[0.00001256367,0.000044922,0.002565567,0.00000791248,0.000006028919,0.0003453184,0.00001550397,0.0009737939,0.9936148,0.000362608,0.002048118,0.000002806964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812936,0.003264706,0.01061911,0.0005117234,0.0001686614,0.0000297869,0.0008374255,0.0003130051,0.002962083],"genre_scores_gemma":[0.9840649,0.001175327,0.005347,0.0001231519,0.00002844463,0.00002675918,0.0009692276,0.0001121657,0.008153163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0016983,"threshold_uncertainty_score":0.005681336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01526907266617386,"score_gpt":0.2231789028221252,"score_spread":0.2079098301559514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}