{"id":"W4309928779","doi":"10.1016/j.ijpharm.2022.122432","title":"A nanodiamond chemotherapeutic folate receptor-targeting prodrug with triggerable drug release","year":2022,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Diamond and Carbon-based Materials Research","field":"Materials Science","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Windsor","funders":"","keywords":"Prodrug; Doxorubicin; Folate receptor; Drug delivery; Pharmacology; Cytotoxicity; Cancer cell; Chemistry; In vivo; Drug; Cytotoxic T cell; In vitro; Biochemistry; Cancer; Chemotherapy; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001933778,0.0001679951,0.0002455432,0.0002290883,0.0002038272,0.0002262427,0.0009274107,0.00002320122,0.004304247],"category_scores_gemma":[0.00007017705,0.0001376694,0.0001077585,0.0001905613,0.00007874327,0.0003394727,0.0001912199,0.0004222966,0.00004353467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003054477,"about_ca_system_score_gemma":0.0005171085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002827613,"about_ca_topic_score_gemma":0.000001310134,"domain_scores_codex":[0.9970509,0.0003065263,0.0005553688,0.000208069,0.001537213,0.0003419305],"domain_scores_gemma":[0.998468,0.000131224,0.0005339794,0.0001244547,0.000567769,0.0001746092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001498651,0.0002969099,0.0003104937,0.00002470364,0.0001068718,0.0001734805,0.0006134284,0.00211994,0.9882164,0.00009033463,0.002425543,0.004123264],"study_design_scores_gemma":[0.002146083,0.0001817425,0.000009281403,0.00004181504,0.00003827413,0.0001657053,0.0003949996,0.0007235321,0.8952433,0.0002773886,0.1005972,0.0001806629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941834,0.0009387392,0.0001190265,0.001623836,0.002288136,0.000166011,0.00007116603,0.00003035267,0.0005793368],"genre_scores_gemma":[0.9962095,0.0002208972,0.001308498,0.0007624759,0.0005304869,0.00001954824,0.00001070301,0.00003766866,0.0009002323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09817163,"threshold_uncertainty_score":0.9966059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01769566345820559,"score_gpt":0.306810647296361,"score_spread":0.2891149838381554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}