{"id":"W4309941554","doi":"10.1038/s41467-022-34262-0","title":"Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Cancer Institute; Instituto de Salud Carlos III; Euskal Herriko Unibertsitatea; National Institutes of Health; Universidad de Navarra; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; Banco Bilbao Vizcaya Argentaria; Ikerbasque, Basque Foundation for Science; Silence Therapeutics; Instituto de Investigación Marqués de Valdecilla; “la Caixa” Foundation; Ministerio de Economía y Competitividad; Spanish Clinical Research Network; Newcastle University; Cancer Research UK; Ministerio de Ciencia e Innovación; Ministerio de Ciencia, Innovación y Universidades; Fundación Científica Asociación Española Contra el Cáncer; Universidad de Málaga; York University; E-Rare; Agencia Estatal de Investigación; Universitat de València; McGill University","keywords":"Endoplasmic reticulum; Acetaminophen; Pharmacology; Cyclin D1; Chemistry; Magnesium; Cell biology; Cyclin; Liver injury; Medicine; Cancer research; Biochemistry; Biology; Cell cycle; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001360775,0.0003044131,0.0002967022,0.0001556024,0.003115632,0.00004306365,0.001954566,0.000751009,0.0004462462],"category_scores_gemma":[0.0002524864,0.0003545138,0.00015097,0.0008215404,0.0001780342,0.0003148374,0.001234733,0.008311934,0.0001640365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004201375,"about_ca_system_score_gemma":0.0001685609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008611718,"about_ca_topic_score_gemma":0.0001428096,"domain_scores_codex":[0.9959621,0.002272666,0.0004246428,0.0004635137,0.0003626508,0.0005144391],"domain_scores_gemma":[0.9969788,0.0004996949,0.0002977675,0.001924805,0.0001520846,0.0001469022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002558819,0.00151761,0.003002153,0.0001614364,0.0001698549,0.00008649094,0.005397111,0.001149652,0.9548461,0.01457177,0.005380936,0.01346094],"study_design_scores_gemma":[0.001453446,0.0001626057,0.002502521,0.00002029509,0.0001003362,0.00002724804,0.0005541987,0.008717172,0.1564881,0.000831958,0.828507,0.000635092],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9416374,0.006851447,0.0001555486,0.006370929,0.00322669,0.002416662,0.000169216,0.000545427,0.03862671],"genre_scores_gemma":[0.9912271,0.0006254989,0.001835287,0.003218453,0.0002961455,0.001170767,0.0001971668,0.00005341722,0.001376087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8231261,"threshold_uncertainty_score":0.9998907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1611027395788933,"score_gpt":0.4177137300851816,"score_spread":0.2566109905062883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}