{"id":"W4309941554","doi":"10.1038/s41467-022-34262-0","title":"Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Cancer Institute; Instituto de Salud Carlos III; Euskal Herriko Unibertsitatea; National Institutes of Health; Universidad de Navarra; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; Banco Bilbao Vizcaya Argentaria; Ikerbasque, Basque Foundation for Science; Silence Therapeutics; Instituto de Investigación Marqués de Valdecilla; “la Caixa” Foundation; Ministerio de Economía y Competitividad; Spanish Clinical Research Network; Newcastle University; Cancer Research UK; Ministerio de Ciencia e Innovación; Ministerio de Ciencia, Innovación y Universidades; Fundación Científica Asociación Española Contra el Cáncer; Universidad de Málaga; York University; E-Rare; Agencia Estatal de Investigación; Universitat de València; McGill University","keywords":"Endoplasmic reticulum; Acetaminophen; Pharmacology; Cyclin D1; Chemistry; Magnesium; Cell biology; Cyclin; Liver injury; Medicine; Cancer research; Biochemistry; Biology; Cell cycle; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009719063,0.0002568499,0.0003916301,0.0002609787,0.0001865005,0.0002436413,0.0002447001,0.0002926097,0.001832408],"category_scores_gemma":[0.0001638087,0.0000904926,0.0002413745,0.0001715792,0.0002227332,0.0002193507,0.0001673064,0.0005836065,0.0003411225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002376713,"about_ca_system_score_gemma":0.0003836976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006972944,"about_ca_topic_score_gemma":0.001284916,"domain_scores_codex":[0.9999336,0.000009873752,0.000005329365,0.00001168483,0.00001326481,0.00002620915],"domain_scores_gemma":[0.9999421,0.000005590546,0.0000174074,0.00000864473,0.00000951836,0.00001678558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002007523,0.0002612766,0.000650105,0.0002048102,0.00003189299,0.00007617299,0.00002982018,0.000195429,0.9842902,0.0002731644,0.0005044411,0.01147511],"study_design_scores_gemma":[0.0002717263,0.002774695,0.006687429,0.0000241917,0.00007683274,0.000199779,0.00008615912,0.001153588,0.9759488,0.0002008467,0.01256474,0.00001129441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882185,0.005112903,0.00261562,0.0004031315,0.0001508175,0.00007674264,0.0004618363,0.0003057989,0.002654784],"genre_scores_gemma":[0.9929623,0.002238192,0.001342217,0.0001376816,0.00002369555,0.00007592132,0.0005160034,0.00003115636,0.002672891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001832408,"threshold_uncertainty_score":0.00612998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1611027395788933,"score_gpt":0.4177137300851816,"score_spread":0.2566109905062883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}