{"id":"W4309944808","doi":"10.1093/hmg/ddac285","title":"Derivation of a minimal functional XIST by combining human and mouse interaction domains","year":2022,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"XIST; Biology; Heterochromatin; Gene silencing; Genetics; RNA interference; X-inactivation; RNA; RNA silencing; Gene; X chromosome; Chromatin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003205949,0.0004990011,0.0002584111,0.0003724207,0.000215261,0.0003778369,0.0006749236,0.0003498252,0.002355778],"category_scores_gemma":[0.0001739112,0.000377,0.0003347097,0.0002750533,0.0002147403,0.0002062092,0.0005513776,0.0007565503,0.00139293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004672126,"about_ca_system_score_gemma":0.0003939941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006463758,"about_ca_topic_score_gemma":0.0008984777,"domain_scores_codex":[0.9997569,0.0000292252,0.00003902779,0.00004554168,0.00008973888,0.00003968763],"domain_scores_gemma":[0.9998574,0.0000178854,0.00003505547,0.00002313404,0.00001867789,0.00004776978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004484992,0.00002790923,0.0001528109,0.00003632262,0.000006248236,0.00004998234,0.00001622457,0.00009761385,0.9978473,0.0003736425,0.00006334191,0.001283639],"study_design_scores_gemma":[0.00004879446,0.0004062141,0.002973716,0.00002575405,0.00004944758,0.0005432797,0.00002170058,0.00113292,0.9638676,0.0001216118,0.03079856,0.00001045849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9365302,0.002194105,0.04912374,0.0002186212,0.0001018597,0.0006251416,0.004432109,0.0004111958,0.006362935],"genre_scores_gemma":[0.919454,0.001699781,0.04267287,0.0001640633,0.00002961308,0.0005154249,0.01783557,0.0002136056,0.01741513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002355778,"threshold_uncertainty_score":0.007880867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0157945843112622,"score_gpt":0.2680237073659035,"score_spread":0.2522291230546413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}