{"id":"W4310009650","doi":"10.1101/2022.11.23.517669","title":"Poly ADP-Ribose Signaling is Dysregulated in Huntington Disease","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Structural Genomics Consortium; University of Toronto; McMaster University","funders":"Canadian Institutes of Health Research; Genentech; National Institute for Health and Care Research; Ionis Pharmaceuticals; PTC Therapeutics; Merck KGaA; McGill University; University College London; European Federation of Pharmaceutical Industries and Associations; Medpace; Genome Canada; F. Hoffmann-La Roche; European Huntington's Disease Network; CHDI Foundation; Medical Research Council; Bayer; National Institutes of Health; Ontario Genomics; Krembil Foundation; Ontario Genomics Institute; Novartis; Pfizer; Bristol-Myers Squibb","keywords":"Huntington's disease; Disease; Ribose; Poly ADP ribose polymerase; Genetics; Neuroscience; Biology; Medicine; Internal medicine; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005957476,0.0001909695,0.0001398711,0.0002304111,0.00009978111,0.0002063938,0.00006911109,0.0002374188,0.0009586246],"category_scores_gemma":[0.00006959448,0.00007492871,0.00009382576,0.0001639236,0.000102997,0.0001009174,0.00009851826,0.0001672043,0.0001620817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001341683,"about_ca_system_score_gemma":0.00004587108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002735704,"about_ca_topic_score_gemma":0.0002872304,"domain_scores_codex":[0.9999539,0.000006628331,0.000005512342,0.00001699666,0.00001082635,0.000006121797],"domain_scores_gemma":[0.9999576,0.000006195033,0.0000170907,0.00000260395,0.000006265392,0.0000102627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002472894,0.00001978901,0.00487155,0.00002714981,0.00001476229,0.0003964493,0.00001866477,0.00004827535,0.9920359,0.00004944147,0.00007548305,0.002195152],"study_design_scores_gemma":[0.0000397672,0.0006627762,0.4799705,0.00002906898,0.00008406826,0.005083393,0.0001372724,0.00255588,0.5063792,0.0005378406,0.004506848,0.00001333411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967496,0.001617299,0.0007911526,0.00004589796,0.00001295306,0.000006830208,0.0003467345,0.00002771656,0.0004018437],"genre_scores_gemma":[0.9983358,0.0004209502,0.0003966124,0.00002693007,0.000004481015,0.000007157084,0.0002646195,0.000003941597,0.0005395258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009586246,"threshold_uncertainty_score":0.003206909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009679144787429875,"score_gpt":0.2240919454381897,"score_spread":0.2144128006507599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}