{"id":"W4310017070","doi":"10.1016/j.ejmech.2022.114958","title":"Design and synthesis of new adamantyl derivatives as promising antiproliferative agents","year":2022,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier de l'Université Laval; Université Laval","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Higher Education Commision, Pakistan; University of Sharjah; Mitacs; Deutscher Akademischer Austauschdienst","keywords":"Chemistry; Cell culture; Carbonic anhydrase; Cytotoxicity; Cytotoxic T cell; Enzyme; Cancer cell; Docking (animal); Stereochemistry; Biochemistry; Cancer; Pharmacology; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007382664,0.00009530893,0.000146109,0.0000267987,0.00008537902,0.000007907913,0.0001182346,0.00001750817,0.0002426816],"category_scores_gemma":[0.0003386615,0.00008475265,0.00005051043,0.00005608999,0.00007189736,0.000006132403,0.00007743054,0.000171655,6.343899e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001295361,"about_ca_system_score_gemma":0.0001252169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.415278e-7,"about_ca_topic_score_gemma":1.722989e-8,"domain_scores_codex":[0.9990035,0.000243065,0.0003023689,0.0001245213,0.0002358315,0.00009071276],"domain_scores_gemma":[0.9993475,0.00002584972,0.000344656,0.00008817441,0.00008534145,0.0001084993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000506957,0.00005871597,0.0001413445,0.00002889206,0.0000646609,0.00006266092,0.0002958612,0.0001231569,0.9862078,0.000001360766,0.009654146,0.00285444],"study_design_scores_gemma":[0.0009118624,0.0007872229,0.0003403097,0.00009724273,0.00003828458,0.0007487559,0.0009831224,0.00002674326,0.9891658,0.00001180591,0.006803595,0.00008521054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98737,0.0009601925,0.007532684,0.0003022954,0.00007747776,0.00005714741,0.000002654792,0.000002966074,0.00369462],"genre_scores_gemma":[0.9974046,0.0001421615,0.00128039,0.0001948608,0.0003097462,8.47352e-7,0.000005232082,0.00001528576,0.0006469296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01003459,"threshold_uncertainty_score":0.3456112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02030450443888724,"score_gpt":0.2467079764144234,"score_spread":0.2264034719755361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}