{"id":"W4310020999","doi":"10.1016/j.bbrep.2022.101397","title":"Distal extracellular teneurin region (teneurin C-terminal associated peptide; TCAP) possesses independent intracellular calcium regulating actions, in vitro: A potential antagonist of corticotropin-releasing factor (CRF)","year":2022,"lang":"en","type":"article","venue":"Biochemistry and Biophysics Reports","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Protagonist Therapeutics","keywords":"Extracellular; Biology; Calcium in biology; Cell biology; Calcium; Cytosol; Intracellular; Biochemistry; Internal medicine; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135107,0.0002882487,0.0002158286,0.0001056382,0.0001387462,0.0002174973,0.0001626821,0.0001952706,0.001222904],"category_scores_gemma":[0.0001103222,0.00009357014,0.0001799805,0.0001059171,0.000155822,0.0001441653,0.0001503145,0.0004932925,0.0002534965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002372834,"about_ca_system_score_gemma":0.0002642442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009248278,"about_ca_topic_score_gemma":0.001937904,"domain_scores_codex":[0.999925,0.00001122621,0.000007216905,0.00001744,0.00001963658,0.00001938254],"domain_scores_gemma":[0.9999435,0.00001421156,0.000008684224,0.00000637077,0.000005569831,0.00002156997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008359895,0.00001520949,0.0000471999,0.0000175197,0.000001995877,0.00002843275,0.000004644787,0.00001596707,0.9992632,0.00002727132,0.00001720423,0.0004775925],"study_design_scores_gemma":[0.00004838706,0.0005715751,0.004389316,0.000004379746,0.00001905827,0.0003917276,0.00002134649,0.0006874886,0.9914142,0.00003903227,0.002409152,0.000004384849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929323,0.002028778,0.00222201,0.0001499444,0.00006801517,0.00003241944,0.0004215191,0.00003138376,0.002113527],"genre_scores_gemma":[0.9908662,0.001722283,0.003188413,0.00008690365,0.00002904982,0.00005561277,0.001103612,0.00001077145,0.002937227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001222904,"threshold_uncertainty_score":0.004091024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01470760457317677,"score_gpt":0.2395656886870544,"score_spread":0.2248580841138776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}