{"id":"W4310020999","doi":"10.1016/j.bbrep.2022.101397","title":"Distal extracellular teneurin region (teneurin C-terminal associated peptide; TCAP) possesses independent intracellular calcium regulating actions, in vitro: A potential antagonist of corticotropin-releasing factor (CRF)","year":2022,"lang":"en","type":"article","venue":"Biochemistry and Biophysics Reports","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Protagonist Therapeutics","keywords":"Extracellular; Biology; Calcium in biology; Cell biology; Calcium; Cytosol; Intracellular; Biochemistry; Internal medicine; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00005873017,0.0003188432,0.000367949,0.00006272933,0.0003267629,0.00006835005,0.0001490424,0.0002044591,0.00002192842],"category_scores_gemma":[0.00006461107,0.0003507652,0.000192822,0.0001949019,0.0001226864,0.00001756856,0.0003038069,0.0003259747,1.300377e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008355839,"about_ca_system_score_gemma":0.0001522339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001113909,"about_ca_topic_score_gemma":0.000001703268,"domain_scores_codex":[0.9976099,0.0001034219,0.0007319401,0.000750874,0.0004216465,0.000382236],"domain_scores_gemma":[0.9986167,0.00001257378,0.0007326387,0.0004022949,0.0001144891,0.0001213211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002445654,0.0003633983,0.001825649,0.0001135164,0.00006107458,0.0007454671,0.00003562005,0.0002269311,0.9945334,0.00000632021,0.00001428468,0.001829764],"study_design_scores_gemma":[0.0004248005,0.0001608124,0.002008916,0.00004246102,0.00004557773,0.001029889,0.0003208024,0.0003359148,0.9950203,0.00004983186,0.0001810532,0.0003796191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975359,0.0009798771,0.0007967379,0.00002979854,0.0002832256,0.0002520606,0.00007133162,0.00002080696,0.00003024291],"genre_scores_gemma":[0.998294,0.0002049851,0.0001785346,0.00001105392,0.0001821867,0.00004381809,0.0005748529,0.0000409089,0.0004696571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001450145,"threshold_uncertainty_score":0.9998944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01470760457317677,"score_gpt":0.2395656886870544,"score_spread":0.2248580841138776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}