{"id":"W4310030087","doi":"10.1101/2022.11.23.22282135","title":"Predicting cognitive decline in a low-dimensional representation of brain morphology","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Advanced Neuroimaging Techniques and Applications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; National Institute on Aging; Fundamental Research Funds for the Central Universities; Center for Advanced Brain Imaging; McDonnell Center for Systems Neuroscience; Alvin J. Siteman Cancer Center; Genentech; National Institutes of Health; IXICO; Servier; National Science Foundation; China Postdoctoral Science Foundation; Foundation for the National Institutes of Health; Stavros Niarchos Foundation; University of Southern California; Eisai; National Natural Science Foundation of China; U.S. Department of Defense; Commonwealth Scientific and Industrial Research Organisation; Northern California Institute for Research and Education; Dana Foundation; H. Lundbeck A/S; Bristol-Myers Squibb; Southwest University; Natural Science Foundation of Chongqing; Université Laval; Natural Sciences and Engineering Research Council of Canada; Child Mind Institute; Pfizer; Biogen; BioClinica; Canadian Institutes of Health Research; Foundation for Barnes-Jewish Hospital; F. Hoffmann-La Roche; Yale University; Novartis Pharmaceuticals Corporation; American Hearing Research Foundation; Biotechnology and Biological Sciences Research Council; Chongqing Postdoctoral Science Foundation; New York State Office of Mental Health; Alzheimer's Association; Leon Levy Foundation; Alzheimer's Disease Neuroimaging Initiative; James S. McDonnell Foundation; Eli Lilly and Company; Alliance de recherche numérique du Canada; Canada First Research Excellence Fund; Brain Research Foundation; Meso Scale Diagnostics; Fok Ying Tung Education Foundation","keywords":"Neurodegeneration; Cognitive decline; Neuroimaging; Cognition; Psychology; Representation (politics); Neuroscience; Cognitive neuroscience; Alzheimer's disease; Pattern recognition (psychology); Artificial intelligence; Medicine; Disease; Computer science; Cognitive psychology; Pathology; Dementia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002133396,0.0006924199,0.0005097009,0.0016399,0.000240467,0.000982788,0.0004204231,0.0005938103,0.0007784857],"category_scores_gemma":[0.004853279,0.0001934272,0.0006556435,0.0007130332,0.0003008411,0.0006482157,0.0007459575,0.0006595178,0.0003841273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005164246,"about_ca_system_score_gemma":0.000407255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005122344,"about_ca_topic_score_gemma":0.003435292,"domain_scores_codex":[0.9994602,0.0001963289,0.00003390246,0.0001652686,0.0000858931,0.00005843469],"domain_scores_gemma":[0.9984397,0.000735995,0.0002129062,0.0001919396,0.0003172432,0.0001021867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001455368,0.0008386081,0.5091517,0.0001591614,0.0007274494,0.0002635323,0.000475376,0.1997328,0.0190591,0.0007574889,0.003576447,0.263803],"study_design_scores_gemma":[0.00001500248,0.0001936266,0.1130901,0.00001533649,0.00002964927,0.0001024852,0.0000950742,0.8835697,0.001840711,0.0007689969,0.0002596341,0.00001971971],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9683542,0.0001942367,0.03021123,0.0001005461,0.00001922314,0.00004221064,0.0004349669,0.0003395774,0.0003038499],"genre_scores_gemma":[0.9880335,0.00005975501,0.01067512,0.00001302773,0.00001004894,0.0000253883,0.0009346589,0.00001154546,0.0002369233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005122344,"threshold_uncertainty_score":0.01128262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07750956191120476,"score_gpt":0.404770311159337,"score_spread":0.3272607492481323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}